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Molecular definition of group 1 innate lymphoid cells in the mouse uterus

Author

Listed:
  • Iva Filipovic

    (NIHR Cambridge Biomedical Research Centre
    University of Cambridge
    University of Cambridge)

  • Laura Chiossone

    (G. Gaslini Institute, Genoa
    Innate Pharma Research Labs, Innate Pharma)

  • Paola Vacca

    (Policlinico San Martino IRCCS per l’Oncologia, Genoa
    University of Genoa
    IRCCS Bambino Gesù Children’s Hospital)

  • Russell S. Hamilton

    (University of Cambridge)

  • Tiziano Ingegnere

    (IRCCS Bambino Gesù Children’s Hospital)

  • Jean-Marc Doisne

    (NIHR Cambridge Biomedical Research Centre
    Pasteur Institute)

  • Delia A. Hawkes

    (NIHR Cambridge Biomedical Research Centre)

  • Maria Cristina Mingari

    (Policlinico San Martino IRCCS per l’Oncologia, Genoa
    University of Genoa
    University of Genova)

  • Andrew M. Sharkey

    (University of Cambridge
    University of Cambridge)

  • Lorenzo Moretta

    (IRCCS Bambino Gesù Children’s Hospital)

  • Francesco Colucci

    (NIHR Cambridge Biomedical Research Centre
    University of Cambridge)

Abstract

Determining the function of uterine lymphocytes is challenging because of the dynamic changes in response to sex hormones and, during pregnancy, to the invading foetal trophoblast cells. Here we provide a genome-wide transcriptome atlas of mouse uterine group 1 innate lymphoid cells (ILCs) at mid-gestation. Tissue-resident Eomes+CD49a+ NK cells (trNK), which resemble human uterine NK cells, are most abundant during early pregnancy, and have gene signatures associated with TGF-β responses and interactions with trophoblast, epithelial, endothelial, smooth muscle cells, leucocytes and extracellular matrix. Conventional NK cells expand late in gestation and may engage in crosstalk with trNK cells involving IL-18 and IFN-γ. Eomes−CD49a+ ILC1s dominate before puberty, and specifically expand in second pregnancies when the expression of the memory cell marker CXCR6 is upregulated. These results identify trNK cells as the cellular hub of uterine group 1 ILCs, and mark CXCR6+ ILC1s as potential memory cells of pregnancy.

Suggested Citation

  • Iva Filipovic & Laura Chiossone & Paola Vacca & Russell S. Hamilton & Tiziano Ingegnere & Jean-Marc Doisne & Delia A. Hawkes & Maria Cristina Mingari & Andrew M. Sharkey & Lorenzo Moretta & Francesco , 2018. "Molecular definition of group 1 innate lymphoid cells in the mouse uterus," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06918-3
    DOI: 10.1038/s41467-018-06918-3
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