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Induced-fit expansion and contraction of a self-assembled nanocube finely responding to neutral and anionic guests

Author

Listed:
  • Yi-Yang Zhan

    (The University of Tokyo)

  • Tatsuo Kojima

    (The University of Tokyo)

  • Takashi Nakamura

    (The University of Tokyo
    University of Tsukuba)

  • Toshihiro Takahashi

    (The University of Tokyo)

  • Satoshi Takahashi

    (The University of Tokyo)

  • Yohei Haketa

    (Ritsumeikan University)

  • Yoshiaki Shoji

    (Tokyo Institute of Technology)

  • Hiromitsu Maeda

    (Ritsumeikan University)

  • Takanori Fukushima

    (Tokyo Institute of Technology)

  • Shuichi Hiraoka

    (The University of Tokyo)

Abstract

Induced-fit or conformational selection is of profound significance in biological regulation. Biological receptors alter their conformation to respond to the shape and electrostatic surfaces of guest molecules. Here we report a water-soluble artificial molecular host that can sensitively respond to the size, shape, and charged state of guest molecules. The molecular host, i.e. nanocube, is an assembled structure consisting of six gear-shaped amphiphiles (GSAs). This nanocube can expand or contract its size upon the encapsulation of neutral and anionic guest molecules with a volume ranging from 74 to 535 Å3 by induced-fit. The responding property of this nanocube, reminiscent of a feature of biological molecules, arises from the fact that the GSAs in the nanocubes are connected to each other only through the hydrophobic effect and very weak intermolecular interactions such as van der Waals and cation-π interactions.

Suggested Citation

  • Yi-Yang Zhan & Tatsuo Kojima & Takashi Nakamura & Toshihiro Takahashi & Satoshi Takahashi & Yohei Haketa & Yoshiaki Shoji & Hiromitsu Maeda & Takanori Fukushima & Shuichi Hiraoka, 2018. "Induced-fit expansion and contraction of a self-assembled nanocube finely responding to neutral and anionic guests," Nature Communications, Nature, vol. 9(1), pages 1-6, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06874-y
    DOI: 10.1038/s41467-018-06874-y
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