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Multi-hierarchical profiling the structure-activity relationships of engineered nanomaterials at nano-bio interfaces

Author

Listed:
  • Xiaoming Cai

    (Soochow University)

  • Jun Dong

    (Wuhan Academy of Agricultural Science)

  • Jing Liu

    (Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS))

  • Huizhen Zheng

    (Soochow University)

  • Chitrada Kaweeteerawat

    (National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA))

  • Fangjun Wang

    (Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS))

  • Zhaoxia Ji

    (University of California
    Living Proof, Inc.)

  • Ruibin Li

    (Soochow University)

Abstract

Increasing concerns over the possible risks of nanotechnology necessitates breakthroughs in structure–activity relationship (SAR) analyses of engineered nanomaterials (ENMs) at nano-bio interfaces. However, current nano-SARs are often based on univariate assessments and fail to provide tiered views on ENM-induced bio-effects. Here we report a multi-hierarchical nano-SAR assessment for a representative ENM, Fe2O3, by metabolomics and proteomics analyses. The established nano-SAR profile allows the visualizing of the contributions of seven basic properties of Fe2O3 to its diverse bio-effects. For instance, although surface reactivity is responsible for Fe2O3-induced cell migration, the inflammatory effects of Fe2O3 are determined by aspect ratio (nanorods) or surface reactivity (nanoplates). These nano-SARs are examined in THP-1 cells and animal lungs, which allow us to decipher the detailed mechanisms including NLRP3 inflammasome pathway and monocyte chemoattractant protein-1-dependent signaling. This study provides more insights for nano-SARs, and may facilitate the tailored design of ENMs to render them desired bio-effects.

Suggested Citation

  • Xiaoming Cai & Jun Dong & Jing Liu & Huizhen Zheng & Chitrada Kaweeteerawat & Fangjun Wang & Zhaoxia Ji & Ruibin Li, 2018. "Multi-hierarchical profiling the structure-activity relationships of engineered nanomaterials at nano-bio interfaces," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06869-9
    DOI: 10.1038/s41467-018-06869-9
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