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Germline variation at 8q24 and prostate cancer risk in men of European ancestry

Author

Listed:
  • Marco Matejcic

    (University of Southern California/Norris Comprehensive Cancer Center)

  • Edward J. Saunders

    (The Institute of Cancer Research)

  • Tokhir Dadaev

    (The Institute of Cancer Research)

  • Mark N. Brook

    (The Institute of Cancer Research)

  • Kan Wang

    (University of Southern California/Norris Comprehensive Cancer Center)

  • Xin Sheng

    (University of Southern California/Norris Comprehensive Cancer Center)

  • Ali Amin Al Olama

    (University of Cambridge
    University of Cambridge)

  • Fredrick R. Schumacher

    (Case Western Reserve University
    University Hospitals)

  • Sue A. Ingles

    (University of Southern California/Norris Comprehensive Cancer Center)

  • Koveela Govindasami

    (The Institute of Cancer Research)

  • Sara Benlloch

    (The Institute of Cancer Research
    University of Cambridge)

  • Sonja I. Berndt

    (National Cancer Institute, NIH)

  • Demetrius Albanes

    (National Cancer Institute, NIH)

  • Stella Koutros

    (National Cancer Institute, NIH)

  • Kenneth Muir

    (University of Manchester
    University of Warwick)

  • Victoria L. Stevens

    (Epidemiology Research Program, American Cancer Society)

  • Susan M. Gapstur

    (Epidemiology Research Program, American Cancer Society)

  • Catherine M. Tangen

    (SWOG Statistical Center, Fred Hutchinson Cancer Research Center)

  • Jyotsna Batra

    (Queensland University of Technology
    Translational Research Institute)

  • Judith Clements

    (Queensland University of Technology
    Translational Research Institute)

  • Henrik Gronberg

    (Karolinska Institute)

  • Nora Pashayan

    (University of Cambridge
    University College London)

  • Johanna Schleutker

    (University of Turku
    Turku University Hospital
    University of Tampere)

  • Alicja Wolk

    (Karolinska Institutet)

  • Catharine West

    (University of Manchester)

  • Lorelei Mucci

    (Harvard School of Public Health)

  • Peter Kraft

    (Harvard T.H. Chan School of Public Health)

  • Géraldine Cancel-Tassin

    (GRC N°5 ONCOTYPE-URO, UPMC Univ Paris 06, Tenon Hospital
    CeRePP, Tenon Hospital)

  • Karina D. Sorensen

    (Aarhus University Hospital
    Aarhus University)

  • Lovise Maehle

    (Oslo University Hospital)

  • Eli M. Grindedal

    (Oslo University Hospital)

  • Sara S. Strom

    (The University of Texas MD Anderson Cancer Center)

  • David E. Neal

    (University of Cambridge
    Li Ka Shing Centre)

  • Freddie C. Hamdy

    (University of Oxford)

  • Jenny L. Donovan

    (University of Bristol, Canynge Hall)

  • Ruth C. Travis

    (University of Oxford)

  • Robert J. Hamilton

    (Princess Margaret Cancer Centre)

  • Barry Rosenstein

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Yong-Jie Lu

    (Queen Mary University of London)

  • Graham G. Giles

    (Cancer Council Victoria
    The University of Melbourne)

  • Adam S. Kibel

    (Brigham and Womens Hospital)

  • Ana Vega

    (Fundación Pública Galega de Medicina Xenómica-SERGAS, Grupo de Medicina Xenómica, CIBERER, IDIS)

  • Jeanette T. Bensen

    (University of North Carolina)

  • Manolis Kogevinas

    (Barcelona Institute for Global Health (ISGlobal)
    CIBER Epidemiología y Salud Pública (CIBERESP)
    IMIM (Hospital del Mar Research Institute)
    Universitat Pompeu Fabra (UPF))

  • Kathryn L. Penney

    (Brigham and Women’s Hospital/Harvard Medical School)

  • Jong Y. Park

    (Moffitt Cancer Center)

  • Janet L. Stanford

    (Fred Hutchinson Cancer Research Center
    University of Washington)

  • Cezary Cybulski

    (Pomeranian Medical University)

  • Børge G. Nordestgaard

    (University of Copenhagen
    Copenhagen University Hospital, Herlev)

  • Hermann Brenner

    (German Cancer Research Center (DKFZ)
    German Cancer Research Center (DKFZ)
    German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT))

  • Christiane Maier

    (University Hospital Ulm)

  • Jeri Kim

    (The University of Texas MD Anderson Cancer Center)

  • Manuel R. Teixeira

    (Portuguese Oncology Institute of Porto
    University of Porto)

  • Susan L. Neuhausen

    (Beckman Research Institute of the City of Hope)

  • Kim Ruyck

    (Basic Medical Sciences)

  • Azad Razack

    (University of Malaya)

  • Lisa F. Newcomb

    (Fred Hutchinson Cancer Research Center
    University of Washington)

  • Davor Lessel

    (University Medical Center Hamburg-Eppendorf)

  • Radka Kaneva

    (Medical University of Sofia)

  • Nawaid Usmani

    (University of Alberta
    University of Alberta)

  • Frank Claessens

    (KU Leuven)

  • Paul A. Townsend

    (University of Manchester)

  • Manuela Gago-Dominguez

    (Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saúde, SERGAS
    University of California San Diego)

  • Monique J. Roobol

    (Erasmus University Medical Center)

  • Florence Menegaux

    (University Paris-Sud, University Paris-Saclay)

  • Kay-Tee Khaw

    (University of Cambridge)

  • Lisa A. Cannon-Albright

    (University of Utah School of Medicine
    George E. Wahlen Department of Veterans Affairs Medical Center)

  • Hardev Pandha

    (The University of Surrey, Guildford)

  • Stephen N. Thibodeau

    (Mayo Clinic)

  • Daniel J. Schaid

    (Mayo Clinic)

  • Fredrik Wiklund

    (Karolinska Institute)

  • Stephen J. Chanock

    (National Cancer Institute, NIH)

  • Douglas F. Easton

    (University of Cambridge
    University of Cambridge)

  • Rosalind A. Eeles

    (The Institute of Cancer Research
    Royal Marsden NHS Foundation Trust)

  • Zsofia Kote-Jarai

    (The Institute of Cancer Research)

  • David V. Conti

    (University of Southern California/Norris Comprehensive Cancer Center)

  • Christopher A. Haiman

    (University of Southern California/Norris Comprehensive Cancer Center)

Abstract

Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p

Suggested Citation

  • Marco Matejcic & Edward J. Saunders & Tokhir Dadaev & Mark N. Brook & Kan Wang & Xin Sheng & Ali Amin Al Olama & Fredrick R. Schumacher & Sue A. Ingles & Koveela Govindasami & Sara Benlloch & Sonja I., 2018. "Germline variation at 8q24 and prostate cancer risk in men of European ancestry," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06863-1
    DOI: 10.1038/s41467-018-06863-1
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    Cited by:

    1. Xintao Qiu & Nadia Boufaied & Tarek Hallal & Avery Feit & Anna Polo & Adrienne M. Luoma & Walaa Alahmadi & Janie Larocque & Giorgia Zadra & Yingtian Xie & Shengqing Gu & Qin Tang & Yi Zhang & Sudeepa , 2022. "MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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