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Ventral pallidum encodes relative reward value earlier and more robustly than nucleus accumbens

Author

Listed:
  • David Ottenheimer

    (Johns Hopkins University)

  • Jocelyn M. Richard

    (Johns Hopkins University
    University of Minnesota)

  • Patricia H. Janak

    (Johns Hopkins University
    Johns Hopkins University
    Johns Hopkins University)

Abstract

The ventral striatopallidal system, a basal ganglia network thought to convert limbic information into behavioral action, includes the nucleus accumbens (NAc) and the ventral pallidum (VP), typically described as a major output of NAc. Here, to investigate how reward-related information is transformed across this circuit, we measure the activity of neurons in NAc and VP when rats receive two highly palatable but differentially preferred rewards, allowing us to track the reward-specific information contained within the neural activity of each region. In VP, we find a prominent preference-related signal that flexibly reports the relative value of reward outcomes across multiple conditions. This reward-specific firing in VP is present in a greater proportion of the population and arises sooner following reward delivery than in NAc. Our findings establish VP as a preeminent value signaler and challenge the existing model of information flow in the ventral basal ganglia.

Suggested Citation

  • David Ottenheimer & Jocelyn M. Richard & Patricia H. Janak, 2018. "Ventral pallidum encodes relative reward value earlier and more robustly than nucleus accumbens," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06849-z
    DOI: 10.1038/s41467-018-06849-z
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    Cited by:

    1. Ana Verónica Domingues & Tawan T. A. Carvalho & Gabriela J. Martins & Raquel Correia & Bárbara Coimbra & Ricardo Bastos-Gonçalves & Marcelina Wezik & Rita Gaspar & Luísa Pinto & Nuno Sousa & Rui M. Co, 2025. "Dynamic representation of appetitive and aversive stimuli in nucleus accumbens shell D1- and D2-medium spiny neurons," Nature Communications, Nature, vol. 16(1), pages 1-20, December.

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