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Decoding the intensity of sensory input by two glutamate receptors in one C. elegans interneuron

Author

Listed:
  • Wenjuan Zou

    (Chinese Academy of Sciences
    Huazhong University of Science and Technology
    Zhejiang University School of Medicine)

  • Jiajun Fu

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Haining Zhang

    (Chinese Academy of Sciences
    Huazhong University of Science and Technology)

  • Kang Du

    (Huazhong University of Science and Technology)

  • Wenming Huang

    (Huazhong University of Science and Technology)

  • Junwei Yu

    (Chinese Academy of Sciences)

  • Shitian Li

    (Zhejiang University School of Medicine)

  • Yuedan Fan

    (Zhejiang University School of Medicine)

  • Howard A. Baylis

    (University of Cambridge)

  • Shangbang Gao

    (Huazhong University of Science and Technology)

  • Rui Xiao

    (University of Florida)

  • Wei Ji

    (University of Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Lijun Kang

    (Zhejiang University School of Medicine)

  • Tao Xu

    (Chinese Academy of Sciences
    Huazhong University of Science and Technology
    University of Chinese Academy of Sciences)

Abstract

How neurons are capable of decoding stimulus intensity and translate this information into complex behavioral outputs is poorly defined. Here, we demonstrate that the C. elegans interneuron AIB regulates two types of behaviors: reversal initiation and feeding suppression in response to different concentrations of quinine. Low concentrations of quinine are decoded in AIB by a low-threshold, fast-inactivation glutamate receptor GLR-1 and translated into reversal initiation. In contrast, high concentrations of quinine are decoded by a high-threshold, slow-inactivation glutamate receptor GLR-5 in AIB. After activation, GLR-5 evokes sustained Ca2+ release from the inositol 1,4,5-trisphosphate (IP3)-sensitive Ca2+ stores and triggers neuropeptide secretion, which in turn activates the downstream neuron RIM and inhibits feeding. Our results reveal that distinct signal patterns in a single interneuron AIB can encode differential behavioral outputs depending on the stimulus intensity, thus highlighting the importance of functional mapping of information propagation at the single-neuron level during connectome construction.

Suggested Citation

  • Wenjuan Zou & Jiajun Fu & Haining Zhang & Kang Du & Wenming Huang & Junwei Yu & Shitian Li & Yuedan Fan & Howard A. Baylis & Shangbang Gao & Rui Xiao & Wei Ji & Lijun Kang & Tao Xu, 2018. "Decoding the intensity of sensory input by two glutamate receptors in one C. elegans interneuron," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06819-5
    DOI: 10.1038/s41467-018-06819-5
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    Cited by:

    1. Chenxi Lin & Yuxin Shan & Zhongyi Wang & Hui Peng & Rong Li & Pingzhou Wang & Junyan He & Weiwei Shen & Zhengxing Wu & Min Guo, 2024. "Molecular and circuit mechanisms underlying avoidance of rapid cooling stimuli in C. elegans," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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