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DNA engineered micromotors powered by metal nanoparticles for motion based cellphone diagnostics

Author

Listed:
  • Mohamed Shehata Draz

    (Harvard Medical School
    Harvard Medical School
    Tanta University)

  • Kamyar Mehrabi Kochehbyoki

    (Harvard Medical School)

  • Anish Vasan

    (Harvard Medical School)

  • Dheerendranath Battalapalli

    (Harvard Medical School)

  • Aparna Sreeram

    (Harvard Medical School)

  • Manoj Kumar Kanakasabapathy

    (Harvard Medical School)

  • Shantanu Kallakuri

    (Harvard Medical School)

  • Athe Tsibris

    (Harvard Medical School
    Harvard Medical School)

  • Daniel R. Kuritzkes

    (Harvard Medical School
    Harvard Medical School)

  • Hadi Shafiee

    (Harvard Medical School
    Harvard Medical School)

Abstract

HIV-1 infection is a major health threat in both developed and developing countries. The integration of mobile health approaches and bioengineered catalytic motors can allow the development of sensitive and portable technologies for HIV-1 management. Here, we report a platform that integrates cellphone-based optical sensing, loop-mediated isothermal DNA amplification and micromotor motion for molecular detection of HIV-1. The presence of HIV-1 RNA in a sample results in the formation of large-sized amplicons that reduce the motion of motors. The change in the motors motion can be accurately measured using a cellphone system as the biomarker for target nucleic acid detection. The presented platform allows the qualitative detection of HIV-1 (n = 54) with 99.1% specificity and 94.6% sensitivity at a clinically relevant threshold value of 1000 virus particles/ml. The cellphone system has the potential to enable the development of rapid and low-cost diagnostics for viruses and other infectious diseases.

Suggested Citation

  • Mohamed Shehata Draz & Kamyar Mehrabi Kochehbyoki & Anish Vasan & Dheerendranath Battalapalli & Aparna Sreeram & Manoj Kumar Kanakasabapathy & Shantanu Kallakuri & Athe Tsibris & Daniel R. Kuritzkes &, 2018. "DNA engineered micromotors powered by metal nanoparticles for motion based cellphone diagnostics," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06727-8
    DOI: 10.1038/s41467-018-06727-8
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    Cited by:

    1. Bangfeng Wang & Yiwei Li & Mengfan Zhou & Yulong Han & Mingyu Zhang & Zhaolong Gao & Zetai Liu & Peng Chen & Wei Du & Xingcai Zhang & Xiaojun Feng & Bi-Feng Liu, 2023. "Smartphone-based platforms implementing microfluidic detection with image-based artificial intelligence," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Huimeng Wang & Yi Fan & Yaqi Hou & Baiyi Chen & Jinmei Lei & Shijie Yu & Xinyu Chen & Xu Hou, 2022. "Host-guest liquid gating mechanism with specific recognition interface behavior for universal quantitative chemical detection," Nature Communications, Nature, vol. 13(1), pages 1-9, December.

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