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The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA

Author

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  • V. Barra

    (CNRS, UMR 144)

  • D. Fachinetti

    (CNRS, UMR 144)

Abstract

Centromeres are the chromosomal domains required to ensure faithful transmission of the genome during cell division. They have a central role in preventing aneuploidy, by orchestrating the assembly of several components required for chromosome separation. However, centromeres also adopt a complex structure that makes them susceptible to being sites of chromosome rearrangements. Therefore, preservation of centromere integrity is a difficult, but important task for the cell. In this review, we discuss how centromeres could potentially be a source of genome instability and how centromere aberrations and rearrangements are linked with human diseases such as cancer.

Suggested Citation

  • V. Barra & D. Fachinetti, 2018. "The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA," Nature Communications, Nature, vol. 9(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06545-y
    DOI: 10.1038/s41467-018-06545-y
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    Cited by:

    1. Natalia Pardo-Lorente & Anestis Gkanogiannis & Luca Cozzuto & Antoni Gañez Zapater & Lorena Espinar & Ritobrata Ghose & Jacqueline Severino & Laura García-López & Rabia Gül Aydin & Laura Martin & Mari, 2024. "Nuclear localization of MTHFD2 is required for correct mitosis progression," Nature Communications, Nature, vol. 15(1), pages 1-23, December.
    2. Ksenia Smurova & Michela Damizia & Carmela Irene & Stefania Stancari & Giovanna Berto & Giulia Perticari & Maria Giuseppina Iacovella & Ilaria D’Ambrosio & Maria Giubettini & Réginald Philippe & Chiar, 2023. "Rio1 downregulates centromeric RNA levels to promote the timely assembly of structurally fit kinetochores," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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