Author
Listed:
- Juliana D. Siqueira
(Blood Systems Research Institute
Programa de Oncovirologia, Instituto Nacional de Câncer)
- Maria Gloria Dominguez-Bello
(Rutgers University)
- Monica Contreras
(Center for Biophysics and Biochemistry, Venezuelan Institute of Scientific Research (IVIC))
- Orlana Lander
(Instituto de Medicina Tropical, Universidad Central de Venezuela)
- Hortensia Caballero-Arias
(Venezuelan Institute of Scientific Research (IVIC))
- Deng Xutao
(Blood Systems Research Institute
University of California at San Francisco)
- Oscar Noya-Alarcon
(Instituto de Medicina Tropical, Universidad Central de Venezuela
Amazonic Center for Research and Control of Tropical Diseases (CAICET))
- Eric Delwart
(Blood Systems Research Institute
University of California at San Francisco)
Abstract
The number of viruses circulating in small isolated human populations may be reduced by viral extinctions and rare introductions. Here we used viral metagenomics to characterize the eukaryotic virome in feces from healthy children from a large urban center and from three Amerindian villages with minimal outside contact. Numerous human enteric viruses, mainly from the Picornaviridae and Caliciviridae families, were sequenced from each of the sites. Multiple children from the same villages shed closely related viruses reflecting frequent transmission clusters. Feces of isolated villagers also contained multiple viral genomes of unknown cellular origin from the Picornavirales order and CRESS-DNA group and higher levels of nematode and protozoan DNA. Despite cultural and geographic isolation, the diversity of enteric human viruses was therefore not reduced in these Amazonian villages. Frequent viral introductions and/or increased susceptibility to enteric infections may account for the complex fecal virome of Amerindian children in isolated villages.
Suggested Citation
Juliana D. Siqueira & Maria Gloria Dominguez-Bello & Monica Contreras & Orlana Lander & Hortensia Caballero-Arias & Deng Xutao & Oscar Noya-Alarcon & Eric Delwart, 2018.
"Complex virome in feces from Amerindian children in isolated Amazonian villages,"
Nature Communications, Nature, vol. 9(1), pages 1-11, December.
Handle:
RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06502-9
DOI: 10.1038/s41467-018-06502-9
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