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A hippocampal circuit linking dorsal CA2 to ventral CA1 critical for social memory dynamics

Author

Listed:
  • Torcato Meira

    (Columbia University
    Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
    ICVS/3B’s - PT Government Associate Laboratory)

  • Felix Leroy

    (Columbia University)

  • Eric W. Buss

    (Columbia University)

  • Azahara Oliva

    (Columbia University)

  • Jung Park

    (Columbia University)

  • Steven A. Siegelbaum

    (Columbia University)

Abstract

Recent results suggest that social memory requires the dorsal hippocampal CA2 region as well as a subset of ventral CA1 neurons. However, it is unclear whether dorsal CA2 and ventral CA1 represent parallel or sequential circuits. Moreover, because evidence implicating CA2 in social memory comes largely from long-term inactivation experiments, the dynamic role of CA2 in social memory remains unclear. Here, we use pharmacogenetics and optogenetics in mice to acutely and reversibly silence dorsal CA2 and its projections to ventral hippocampus. We show that dorsal CA2 activity is critical for encoding, consolidation, and recall phases of social memory. Moreover, dorsal CA2 contributes to social memory by providing strong excitatory input to the same subregion of ventral CA1 that contains the subset of neurons implicated in social memory. Thus, our studies provide new insights into a dorsal CA2 to ventral CA1 circuit whose dynamic activity is necessary for social memory.

Suggested Citation

  • Torcato Meira & Felix Leroy & Eric W. Buss & Azahara Oliva & Jung Park & Steven A. Siegelbaum, 2018. "A hippocampal circuit linking dorsal CA2 to ventral CA1 critical for social memory dynamics," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06501-w
    DOI: 10.1038/s41467-018-06501-w
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    Cited by:

    1. Myung Chung & Katsutoshi Imanaka & Ziyan Huang & Akiyuki Watarai & Mu-Yun Wang & Kentaro Tao & Hirotaka Ejima & Tomomi Aida & Guoping Feng & Teruhiro Okuyama, 2024. "Conditional knockout of Shank3 in the ventral CA1 by quantitative in vivo genome-editing impairs social memory in mice," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    2. Elise C. Cope & Samantha H. Wang & Renée C. Waters & Isha R. Gore & Betsy Vasquez & Blake J. Laham & Elizabeth Gould, 2023. "Activation of the CA2-ventral CA1 pathway reverses social discrimination dysfunction in Shank3B knockout mice," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Eunji Kong & Kyu-Hee Lee & Jongrok Do & Pilhan Kim & Doyun Lee, 2023. "Dynamic and stable hippocampal representations of social identity and reward expectation support associative social memory in male mice," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    4. Nahoko Kuga & Ryota Nakayama & Shota Morikawa & Haruya Yagishita & Daichi Konno & Hiromi Shiozaki & Natsumi Honjoya & Yuji Ikegaya & Takuya Sasaki, 2023. "Hippocampal sharp wave ripples underlie stress susceptibility in male mice," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    5. Rui Dang & An Liu & Yu Zhou & Xingcan Li & Miao Wu & Kun Cao & Yanghong Meng & Haiwang Zhang & Guangming Gan & Wei Xie & Zhengping Jia, 2024. "Astrocytic neuroligin 3 regulates social memory and synaptic plasticity through adenosine signaling in male mice," Nature Communications, Nature, vol. 15(1), pages 1-22, December.

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