IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-06462-0.html
   My bibliography  Save this article

Diet-induced adaptive thermogenesis requires neuropeptide FF receptor-2 signalling

Author

Listed:
  • Lei Zhang

    (Garvan Institute of Medical Research, St. Vincent’s Hospital
    St. Vincent’s Clinical School, University of NSW)

  • Chi Kin Ip

    (Garvan Institute of Medical Research, St. Vincent’s Hospital)

  • I-Chieh J. Lee

    (Garvan Institute of Medical Research, St. Vincent’s Hospital)

  • Yue Qi

    (Garvan Institute of Medical Research, St. Vincent’s Hospital)

  • Felicia Reed

    (Garvan Institute of Medical Research, St. Vincent’s Hospital)

  • Tim Karl

    (Western Sydney University
    Neuroscience Research Australia
    University of NSW)

  • Jac Kee Low

    (Neuroscience Research Australia)

  • Ronaldo F. Enriquez

    (Garvan Institute of Medical Research, St. Vincent’s Hospital
    Garvan Institute of Medical Research, St Vincent’s Hospital)

  • Nicola J. Lee

    (Garvan Institute of Medical Research, St. Vincent’s Hospital
    St. Vincent’s Clinical School, University of NSW)

  • Paul A. Baldock

    (University of NSW
    Garvan Institute of Medical Research, St Vincent’s Hospital
    University of NSW)

  • Herbert Herzog

    (Garvan Institute of Medical Research, St. Vincent’s Hospital
    University of NSW
    University of NSW)

Abstract

Excess caloric intake results in increased fat accumulation and an increase in energy expenditure via diet-induced adaptive thermogenesis; however, the underlying mechanisms controlling these processes are unclear. Here we identify the neuropeptide FF receptor-2 (NPFFR2) as a critical regulator of diet-induced thermogenesis and bone homoeostasis. Npffr2−/− mice exhibit a stronger bone phenotype and when fed a HFD display exacerbated obesity associated with a failure in activating brown adipose tissue (BAT) thermogenic response to energy excess, whereas the activation of cold-induced BAT thermogenesis is unaffected. NPFFR2 signalling is required to maintain basal arcuate nucleus NPY mRNA expression. Lack of NPFFR2 signalling leads to a decrease in BAT thermogenesis under HFD conditions with significantly lower UCP-1 and PGC-1α levels in the BAT. Together, these data demonstrate that NPFFR2 signalling promotes diet-induced thermogenesis via a novel hypothalamic NPY-dependent circuitry thereby coupling energy homoeostasis with energy partitioning to adipose and bone tissue.

Suggested Citation

  • Lei Zhang & Chi Kin Ip & I-Chieh J. Lee & Yue Qi & Felicia Reed & Tim Karl & Jac Kee Low & Ronaldo F. Enriquez & Nicola J. Lee & Paul A. Baldock & Herbert Herzog, 2018. "Diet-induced adaptive thermogenesis requires neuropeptide FF receptor-2 signalling," Nature Communications, Nature, vol. 9(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06462-0
    DOI: 10.1038/s41467-018-06462-0
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-06462-0
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-018-06462-0?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06462-0. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.