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Maternal gut and breast milk microbiota affect infant gut antibiotic resistome and mobile genetic elements

Author

Listed:
  • Katariina Pärnänen

    (University of Helsinki)

  • Antti Karkman

    (University of Gothenburg
    Center for Antibiotic Resistance research (CARe) at University of Gothenburg
    University of Helsinki)

  • Jenni Hultman

    (University of Helsinki)

  • Christina Lyra

    (University of Helsinki)

  • Johan Bengtsson-Palme

    (University of Gothenburg
    Center for Antibiotic Resistance research (CARe) at University of Gothenburg
    University of Wisconsin-Madison)

  • D. G. Joakim Larsson

    (University of Gothenburg
    Center for Antibiotic Resistance research (CARe) at University of Gothenburg)

  • Samuli Rautava

    (University of Turku and Turku University Hospital)

  • Erika Isolauri

    (University of Turku and Turku University Hospital)

  • Seppo Salminen

    (University of Turku)

  • Himanshu Kumar

    (University of Turku)

  • Reetta Satokari

    (University of Helsinki)

  • Marko Virta

    (University of Helsinki)

Abstract

The infant gut microbiota has a high abundance of antibiotic resistance genes (ARGs) compared to adults, even in the absence of antibiotic exposure. Here we study potential sources of infant gut ARGs by performing metagenomic sequencing of breast milk, as well as infant and maternal gut microbiomes. We find that fecal ARG and mobile genetic element (MGE) profiles of infants are more similar to those of their own mothers than to those of unrelated mothers. MGEs in mothers’ breast milk are also shared with their own infants. Termination of breastfeeding and intrapartum antibiotic prophylaxis of mothers, which have the potential to affect microbial community composition, are associated with higher abundances of specific ARGs, the composition of which is largely shaped by bacterial phylogeny in the infant gut. Our results suggest that infants inherit the legacy of past antibiotic consumption of their mothers via transmission of genes, but microbiota composition still strongly impacts the overall resistance load.

Suggested Citation

  • Katariina Pärnänen & Antti Karkman & Jenni Hultman & Christina Lyra & Johan Bengtsson-Palme & D. G. Joakim Larsson & Samuli Rautava & Erika Isolauri & Seppo Salminen & Himanshu Kumar & Reetta Satokari, 2018. "Maternal gut and breast milk microbiota affect infant gut antibiotic resistome and mobile genetic elements," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06393-w
    DOI: 10.1038/s41467-018-06393-w
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    Cited by:

    1. Achal Dhariwal & Polona Rajar & Gabriela Salvadori & Heidi Aarø Åmdal & Dag Berild & Ola Didrik Saugstad & Drude Fugelseth & Gorm Greisen & Ulf Dahle & Kirsti Haaland & Fernanda Cristina Petersen, 2024. "Prolonged hospitalization signature and early antibiotic effects on the nasopharyngeal resistome in preterm infants," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Yunyan Zhou & Jingquan Li & Fei Huang & Huashui Ai & Jun Gao & Congying Chen & Lusheng Huang, 2023. "Characterization of the pig lower respiratory tract antibiotic resistome," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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