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Structural insights into modulation and selectivity of transsynaptic neurexin–LRRTM interaction

Author

Listed:
  • Atsushi Yamagata

    (The University of Tokyo
    The University of Tokyo
    CREST, JST
    The University of Tokyo)

  • Sakurako Goto-Ito

    (The University of Tokyo
    The University of Tokyo
    CREST, JST)

  • Yusuke Sato

    (The University of Tokyo
    The University of Tokyo
    CREST, JST
    The University of Tokyo)

  • Tomoko Shiroshima

    (The University of Tokyo
    The University of Tokyo
    CREST, JST)

  • Asami Maeda

    (The University of Tokyo
    The University of Tokyo
    CREST, JST)

  • Masahiko Watanabe

    (Hokkaido University Faculty of Medicine)

  • Takashi Saitoh

    (Hokkaido University of Science)

  • Katsumi Maenaka

    (Hokkaido University
    Hokkaido University)

  • Tohru Terada

    (The University of Tokyo)

  • Tomoyuki Yoshida

    (University of Toyama
    PRESTO, JST)

  • Takeshi Uemura

    (CREST, JST
    Shinshu University
    Shinshu University)

  • Shuya Fukai

    (The University of Tokyo
    The University of Tokyo
    CREST, JST
    The University of Tokyo)

Abstract

Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) function as postsynaptic organizers that induce excitatory synapses. Neurexins (Nrxns) and heparan sulfate proteoglycans have been identified as presynaptic ligands for LRRTMs. Specifically, LRRTM1 and LRRTM2 bind to the Nrxn splice variant lacking an insert at the splice site 4 (S4). Here, we report the crystal structure of the Nrxn1β–LRRTM2 complex at 3.4 Å resolution. The Nrxn1β–LRRTM2 interface involves Ca2+-mediated interactions and overlaps with the Nrxn–neuroligin interface. Together with structure-based mutational analyses at the molecular and cellular levels, the present structural analysis unveils the mechanism of selective binding between Nrxn and LRRTM1/2 and its modulation by the S4 insertion of Nrxn.

Suggested Citation

  • Atsushi Yamagata & Sakurako Goto-Ito & Yusuke Sato & Tomoko Shiroshima & Asami Maeda & Masahiko Watanabe & Takashi Saitoh & Katsumi Maenaka & Tohru Terada & Tomoyuki Yoshida & Takeshi Uemura & Shuya F, 2018. "Structural insights into modulation and selectivity of transsynaptic neurexin–LRRTM interaction," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06333-8
    DOI: 10.1038/s41467-018-06333-8
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    Cited by:

    1. Konstantina Liouta & Malgorzata Lubas & Vasika Venugopal & Julia Chabbert & Caroline Jeannière & Candice Diaz & Matthieu Munier & Béatrice Tessier & Stéphane Claverol & Alexandre Favereaux & Matthieu , 2024. "LRRTM2 controls presynapse nano-organization and AMPA receptor sub-positioning through Neurexin-binding interface," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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