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Honey bee Royalactin unlocks conserved pluripotency pathway in mammals

Author

Listed:
  • Derrick C. Wan

    (Stanford University School of Medicine
    Stanford University School of Medicine)

  • Stefanie L. Morgan

    (Stanford University School of Medicine
    Stanford University School of Medicine)

  • Andrew L. Spencley

    (Stanford University School of Medicine)

  • Natasha Mariano

    (Stanford University School of Medicine)

  • Erin Y. Chang

    (Stanford University School of Medicine)

  • Gautam Shankar

    (Stanford University School of Medicine)

  • Yunhai Luo

    (Stanford University School of Medicine)

  • Ted H. Li

    (Stanford University School of Medicine)

  • Dana Huh

    (Stanford University School of Medicine)

  • Star K. Huynh

    (Stanford University School of Medicine)

  • Jasmine M. Garcia

    (Stanford University School of Medicine)

  • Cole M. Dovey

    (Stanford University School of Medicine)

  • Jennifer Lumb

    (Stanford University School of Medicine)

  • Ling Liu

    (Stanford University School of Medicine)

  • Katharine V. Brown

    (Stanford University School of Medicine)

  • Abel Bermudez

    (Stanford University School of Medicine)

  • Richard Luong

    (Stanford University School of Medicine)

  • Hong Zeng

    (Stanford University School of Medicine)

  • Victoria L. Mascetti

    (Stanford University School of Medicine)

  • Sharon J. Pitteri

    (Stanford University School of Medicine)

  • Jordon Wang

    (LakePharma, Inc.)

  • Hua Tu

    (LakePharma, Inc.)

  • Marco Quarta

    (Stanford University School of Medicine)

  • Vittorio Sebastiano

    (Stanford University School of Medicine)

  • Roel Nusse

    (Stanford University School of Medicine)

  • Thomas A. Rando

    (Stanford University School of Medicine)

  • Jan E. Carette

    (Stanford University School of Medicine)

  • J. Fernando Bazan

    (R&D Systems, Inc)

  • Kevin C. Wang

    (Stanford University School of Medicine
    Stanford University School of Medicine
    Veterans Affairs Palo Alto Healthcare System)

Abstract

Royal jelly is the queen-maker for the honey bee Apis mellifera, and has cross-species effects on longevity, fertility, and regeneration in mammals. Despite this knowledge, how royal jelly or its components exert their myriad effects has remained poorly understood. Using mouse embryonic stem cells as a platform, here we report that through its major protein component Royalactin, royal jelly can maintain pluripotency by activating a ground-state pluripotency-like gene network. We further identify Regina, a mammalian structural analog of Royalactin that also induces a naive-like state in mouse embryonic stem cells. This reveals an important innate program for stem cell self-renewal with broad implications in understanding the molecular regulation of stem cell fate across species.

Suggested Citation

  • Derrick C. Wan & Stefanie L. Morgan & Andrew L. Spencley & Natasha Mariano & Erin Y. Chang & Gautam Shankar & Yunhai Luo & Ted H. Li & Dana Huh & Star K. Huynh & Jasmine M. Garcia & Cole M. Dovey & Je, 2018. "Honey bee Royalactin unlocks conserved pluripotency pathway in mammals," Nature Communications, Nature, vol. 9(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06256-4
    DOI: 10.1038/s41467-018-06256-4
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