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A naturally protective epitope of limited variability as an influenza vaccine target

Author

Listed:
  • Craig P. Thompson

    (University of Oxford
    University of Oxford)

  • José Lourenço

    (University of Oxford)

  • Adam A. Walters

    (University of Oxford)

  • Uri Obolski

    (University of Oxford)

  • Matthew Edmans

    (University of Oxford
    University of Oxford)

  • Duncan S. Palmer

    (University of Oxford)

  • Kreepa Kooblall

    (University of Oxford)

  • George W. Carnell

    (University of Kent)

  • Daniel O’Connor

    (University of Oxford, and the NIHR Oxford Biomedical Research Centre)

  • Thomas A. Bowden

    (University of Oxford)

  • Oliver G. Pybus

    (University of Oxford)

  • Andrew J. Pollard

    (University of Oxford, and the NIHR Oxford Biomedical Research Centre)

  • Nigel J. Temperton

    (University of Kent)

  • Teresa Lambe

    (University of Oxford)

  • Sarah C. Gilbert

    (University of Oxford)

  • Sunetra Gupta

    (University of Oxford)

Abstract

Current antigenic targets for influenza vaccine development are either highly immunogenic epitopes of high variability or conserved epitopes of low immunogenicity. This requires continuous update of the variable epitopes in the vaccine formulation or boosting of immunity to invariant epitopes of low natural efficacy. Here we identify a highly immunogenic epitope of limited variability in the head domain of the H1 haemagglutinin protein. We show that a cohort of young children exhibit natural immunity to a set of historical influenza strains which they could not have previously encountered and that this is partially mediated through the epitope. Furthermore, vaccinating mice with these epitope conformations can induce immunity to human H1N1 influenza strains that have circulated since 1918. The identification of epitopes of limited variability offers a mechanism by which a universal influenza vaccine can be created; these vaccines would also have the potential to protect against newly emerging influenza strains.

Suggested Citation

  • Craig P. Thompson & José Lourenço & Adam A. Walters & Uri Obolski & Matthew Edmans & Duncan S. Palmer & Kreepa Kooblall & George W. Carnell & Daniel O’Connor & Thomas A. Bowden & Oliver G. Pybus & And, 2018. "A naturally protective epitope of limited variability as an influenza vaccine target," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06228-8
    DOI: 10.1038/s41467-018-06228-8
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    Cited by:

    1. Hannah Klim & Timothy William & Jack Mellors & Caolann Brady & Giri S. Rajahram & Tock H. Chua & Helena Brazal Monzó & Jecelyn Leslie John & Kelly Costa & Mohammad Saffree Jeffree & Nigel J. Temperton, 2024. "Serological analysis in humans in Malaysian Borneo suggests prior exposure to H5 avian influenza near migratory shorebird habitats," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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