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"RETRACTED ARTICLE: Vibrio parahaemolyticus RhsP represents a widespread group of pro-effectors for type VI secretion systems

Author

Listed:
  • Nan Jiang

    (University of Macau)

  • Le Tang

    (University of Calgary
    University of Calgary
    University of Calgary)

  • Ruiqiang Xie

    (University of Macau)

  • Zhi Li

    (University of Macau)

  • Brianne Burkinshaw

    (University of Calgary
    University of Calgary
    University of Calgary)

  • Xiaoye Liang

    (Shanghai Jiao Tong University)

  • Dylan Sosa

    (Saint Louis University)

  • L. Aravind

    (National Institutes of Health)

  • Tao Dong

    (University of Calgary
    University of Calgary
    University of Calgary
    Shanghai Jiao Tong University)

  • Dapeng Zhang

    (Saint Louis University
    Saint Louis University)

  • Jun Zheng

    (University of Macau)

Abstract

Type VI secretion systems (T6SSs) translocate effector proteins, such as Rhs toxins, to eukaryotic cells or prokaryotic competitors. All T6SS Rhs-type effectors characterized thus far contain a PAAR motif or a similar structure. Here, we describe a T6SS-dependent delivery mechanism for a subset of Rhs proteins that lack a PAAR motif. We show that the N-terminal Rhs domain of protein RhsP (or VP1517) from Vibrio parahaemolyticus inhibits the activity of the C-terminal DNase domain. Upon auto-proteolysis, the Rhs fragment remains inside the cells, and the C-terminal region interacts with PAAR2 and is secreted by T6SS2; therefore, RhsP acts as a pro-effector. Furthermore, we show that RhsP contributes to the control of certain “social cheaters” (opaR mutants). Genes encoding proteins with similar Rhs and PAAR-interacting domains, but diverse C-terminal regions, are widely distributed among Vibrio species.

Suggested Citation

  • Nan Jiang & Le Tang & Ruiqiang Xie & Zhi Li & Brianne Burkinshaw & Xiaoye Liang & Dylan Sosa & L. Aravind & Tao Dong & Dapeng Zhang & Jun Zheng, 2018. ""RETRACTED ARTICLE: Vibrio parahaemolyticus RhsP represents a widespread group of pro-effectors for type VI secretion systems," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06201-5
    DOI: 10.1038/s41467-018-06201-5
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