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Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments

Author

Listed:
  • Hiroyuki Yoshitomi

    (Kyoto University
    Kyoto University)

  • Shio Kobayashi

    (Joslin Diabetes Center)

  • Aya Miyagawa-Hayashino

    (Kyoto University Hospital)

  • Akinori Okahata

    (Kyoto University Graduate School of Medicine)

  • Kohei Doi

    (Kyoto University Graduate School of Medicine)

  • Kohei Nishitani

    (Kyoto University Graduate School of Medicine)

  • Koichi Murata

    (Kyoto University Graduate School of Medicine)

  • Hiromu Ito

    (Kyoto University Graduate School of Medicine)

  • Tatsuaki Tsuruyama

    (Kyoto University Graduate School of Medicine, Yoshida-Konoe-Cho)

  • Hironori Haga

    (Kyoto University Hospital)

  • Shuichi Matsuda

    (Kyoto University Graduate School of Medicine)

  • Junya Toguchida

    (Kyoto University
    Kyoto University)

Abstract

In human inflammatory sites, PD-1hiCXCR5−CD4+ T cells are involved in the formation of ectopic lymphoid-like structures (ELSs) by the secretion of chemokine CXCL13, but how the transcription of CXCL13 is regulated in CD4+ T cells is still unclear. Here we show that Sox4 is a key transcription factor for CXCL13 production in human CD4+ T cells under inflammatory conditions. In vitro TGF-β+, IL-2-neutralizing culture conditions give rise to PD-1hiCXCR5−CD4+ T cells that preferentially express CXCL13, and transcriptome analysis and lentiviral overexpression indicate Sox4 association with the CXCL13 transcription. In vivo, Sox4 is significantly upregulated in synovial CD4+ T cells, when compared with blood CD4+ T cells, from patients with rheumatoid arthritis (RA), and further correlates with ELS formation in RA synovium. Overall, our studies suggest that Sox4 contributes to CXCL13 production and ELS formation at inflammatory sites in humans.

Suggested Citation

  • Hiroyuki Yoshitomi & Shio Kobayashi & Aya Miyagawa-Hayashino & Akinori Okahata & Kohei Doi & Kohei Nishitani & Koichi Murata & Hiromu Ito & Tatsuaki Tsuruyama & Hironori Haga & Shuichi Matsuda & Junya, 2018. "Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06187-0
    DOI: 10.1038/s41467-018-06187-0
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    Cited by:

    1. Taehyeung Kim & Marta Martínez-Bonet & Qiang Wang & Nicolaj Hackert & Jeffrey A. Sparks & Yuriy Baglaenko & Byunghee Koh & Roxane Darbousset & Raquel Laza-Briviesca & Xiaoting Chen & Vitor R. C. Aguia, 2024. "Non-coding autoimmune risk variant defines role for ICOS in T peripheral helper cell development," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Alexandra Argyriou & Marc H. Wadsworth & Adrian Lendvai & Stephen M. Christensen & Aase H. Hensvold & Christina Gerstner & Annika Vollenhoven & Kellie Kravarik & Aaron Winkler & Vivianne Malmström & K, 2022. "Single cell sequencing identifies clonally expanded synovial CD4+ TPH cells expressing GPR56 in rheumatoid arthritis," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Takuya Harada & Yoshikane Kikushige & Toshihiro Miyamoto & Kazuko Uno & Hiroaki Niiro & Atsushi Kawakami & Tomohiro Koga & Koichi Akashi & Kazuyuki Yoshizaki, 2023. "Peripheral helper-T-cell-derived CXCL13 is a crucial pathogenic factor in idiopathic multicentric Castleman disease," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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