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Different patterns of clonal evolution among different sarcoma subtypes followed for up to 25 years

Author

Listed:
  • Jakob Hofvander

    (Lund University)

  • Björn Viklund

    (Uppsala University)

  • Anders Isaksson

    (Uppsala University)

  • Otte Brosjö

    (Karolinska Hospital)

  • Fredrik Vult von Steyern

    (Clinical Sciences, Lund University and Skåne University Hospital)

  • Pehr Rissler

    (University and Regional Laboratories Region Skåne)

  • Nils Mandahl

    (Lund University)

  • Fredrik Mertens

    (Lund University
    University and Regional Laboratories Region Skåne)

Abstract

To compare clonal evolution in tumors arising through different mechanisms, we selected three types of sarcoma—amplicon-driven well-differentiated liposarcoma (WDLS), gene fusion-driven myxoid liposarcoma (MLS), and sarcomas with complex genomes (CXS)—and assessed the dynamics of chromosome and nucleotide level mutations by cytogenetics, SNP array analysis and whole-exome sequencing. Here we show that the extensive single-cell variation in WDLS has minor impact on clonal key amplicons in chromosome 12. In addition, only a few of the single nucleotide variants in WDLS were present in more than one lesion, suggesting that such mutations are of little significance in tumor development. MLS displays few mutations other than the FUS-DDIT3 fusion, and the primary tumor is genetically sometimes much more complex than its relapses, whereas CXS in general shows a gradual increase of both nucleotide- and chromosome–level mutations, similar to what has been described in carcinomas.

Suggested Citation

  • Jakob Hofvander & Björn Viklund & Anders Isaksson & Otte Brosjö & Fredrik Vult von Steyern & Pehr Rissler & Nils Mandahl & Fredrik Mertens, 2018. "Different patterns of clonal evolution among different sarcoma subtypes followed for up to 25 years," Nature Communications, Nature, vol. 9(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06098-0
    DOI: 10.1038/s41467-018-06098-0
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    Cited by:

    1. Nadège Gruel & Chloé Quignot & Laëtitia Lesage & Sophie El Zein & Sylvie Bonvalot & Dimitri Tzanis & Khadija Ait Rais & Fabien Quinquis & Bastien Manciot & Julien Vibert & Nadine El Tannir & Ahmed Dah, 2024. "Cellular origin and clonal evolution of human dedifferentiated liposarcoma," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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