IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-06089-1.html
   My bibliography  Save this article

Spatiotemporal segregation of human marginal zone and memory B cell populations in lymphoid tissue

Author

Listed:
  • Yuan Zhao

    (Guy’s Campus)

  • Mohamed Uduman

    (Yale University School of Medicine)

  • Jacqueline H. Y. Siu

    (University of Cambridge)

  • Thomas J. Tull

    (Guy’s Campus)

  • Jeremy D. Sanderson

    (Guy’s Campus)

  • Yu-Chang Bryan Wu

    (King’s College London)

  • Julian Q. Zhou

    (Yale University)

  • Nedyalko Petrov

    (Guy’s and St. Thomas’ NHS Trust)

  • Richard Ellis

    (Guy’s and St. Thomas’ NHS Trust)

  • Katrina Todd

    (Guy’s and St. Thomas’ NHS Trust)

  • Konstantia-Maria Chavele

    (Guy’s Campus)

  • William Guesdon

    (Guy’s Campus)

  • Anna Vossenkamper

    (Blizard Institute, Whitechapel)

  • Wayel Jassem

    (King’s College Hospital, Denmark Hill)

  • David P. D’Cruz

    (Guy’s Campus)

  • David J. Fear

    (Guy’s Campus)

  • Susan John

    (Guy’s Campus)

  • Dagmar Scheel-Toellner

    (University of Birmingham)

  • Claire Hopkins

    (Guy’s Campus)

  • Estefania Moreno

    (Blizard Institute, Whitechapel)

  • Natalie L. Woodman

    (Guy’s Campus)

  • Francesca Ciccarelli

    (Guy’s Campus)

  • Susanne Heck

    (Guy’s and St. Thomas’ NHS Trust)

  • Steven H. Kleinstein

    (Yale University School of Medicine
    Yale University
    Yale University School of Medicine)

  • Mats Bemark

    (University of Gothenburg)

  • Jo Spencer

    (Guy’s Campus)

Abstract

Human memory B cells and marginal zone (MZ) B cells share common features such as the expression of CD27 and somatic mutations in their IGHV and BCL6 genes, but the relationship between them is controversial. Here, we show phenotypic progression within lymphoid tissues as MZ B cells emerge from the mature naïve B cell pool via a precursor CD27−CD45RBMEM55+ population distant from memory cells. By imaging mass cytometry, we find that MZ B cells and memory B cells occupy different microanatomical niches in organised gut lymphoid tissues. Both populations disseminate widely between distant lymphoid tissues and blood, and both diversify their IGHV repertoire in gut germinal centres (GC), but nevertheless remain largely clonally separate. MZ B cells are therefore not developmentally contiguous with or analogous to classical memory B cells despite their shared ability to transit through GC, where somatic mutations are acquired.

Suggested Citation

  • Yuan Zhao & Mohamed Uduman & Jacqueline H. Y. Siu & Thomas J. Tull & Jeremy D. Sanderson & Yu-Chang Bryan Wu & Julian Q. Zhou & Nedyalko Petrov & Richard Ellis & Katrina Todd & Konstantia-Maria Chavel, 2018. "Spatiotemporal segregation of human marginal zone and memory B cell populations in lymphoid tissue," Nature Communications, Nature, vol. 9(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06089-1
    DOI: 10.1038/s41467-018-06089-1
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-06089-1
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-018-06089-1?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Lucia Montorsi & Michael J. Pitcher & Yuan Zhao & Chiara Dionisi & Alicia Demonti & Thomas J. Tull & Pawan Dhami & Richard J. Ellis & Cynthia Bishop & Jeremy D. Sanderson & Sahil Jain & David D’Cruz &, 2024. "Double-negative B cells and DNASE1L3 colocalise with microbiota in gut-associated lymphoid tissue," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Nannan Guo & Na Li & Li Jia & Qinyue Jiang & Mette Schreurs & Vincent Unen & Susana M. Chuva Sousa Lopes & Alexandra A. Vloemans & Jeroen Eggermont & Boudewijn Lelieveldt & Frank J. T. Staal & Noel F., 2023. "Immune subset-committed proliferating cells populate the human foetal intestine throughout the second trimester of gestation," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06089-1. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.