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Structure of the herpes simplex virus type 2 C-capsid with capsid-vertex-specific component

Author

Listed:
  • Jialing Wang

    (Chinese Academy of Science
    University of Chinese Academy of Sciences)

  • Shuai Yuan

    (Chinese Academy of Science)

  • Dongjie Zhu

    (Chinese Academy of Science)

  • Hao Tang

    (Hunan Normal University)

  • Nan Wang

    (Chinese Academy of Science
    University of Chinese Academy of Sciences)

  • Wenyuan Chen

    (Hunan Normal University)

  • Qiang Gao

    (Chinese Academy of Science
    Sinovac Biotech Co., Ltd)

  • Yuhua Li

    (National Institutes for Food and Drug Control)

  • Junzhi Wang

    (National Institutes for Food and Drug Control)

  • Hongrong Liu

    (Hunan Normal University)

  • Xinzheng Zhang

    (Chinese Academy of Science
    University of Chinese Academy of Sciences)

  • Zihe Rao

    (Chinese Academy of Science
    University of Chinese Academy of Sciences
    ShanghaiTech University
    Nankai University)

  • Xiangxi Wang

    (Chinese Academy of Science
    University of Chinese Academy of Sciences)

Abstract

Herpes simplex viruses (HSVs) cause human oral and genital ulcer diseases. Patients with HSV-2 have a higher risk of acquiring a human immunodeficiency virus infection. HSV-2 is a member of the α-herpesvirinae subfamily that together with the β- and γ-herpesvirinae subfamilies forms the Herpesviridae family. Here, we report the cryo-electron microscopy structure of the HSV-2 C-capsid with capsid-vertex-specific component (CVSC) that was determined at 3.75 Å using a block-based reconstruction strategy. We present atomic models of multiple conformers for the capsid proteins (VP5, VP23, VP19C, and VP26) and CVSC. Comparison of the HSV-2 homologs yields information about structural similarities and differences between the three herpesviruses sub-families and we identify α-herpesvirus-specific structural features. The hetero-pentameric CVSC, consisting of a UL17 monomer, a UL25 dimer and a UL36 dimer, is bound tightly by a five-helix bundle that forms extensive networks of subunit contacts with surrounding capsid proteins, which reinforce capsid stability.

Suggested Citation

  • Jialing Wang & Shuai Yuan & Dongjie Zhu & Hao Tang & Nan Wang & Wenyuan Chen & Qiang Gao & Yuhua Li & Junzhi Wang & Hongrong Liu & Xinzheng Zhang & Zihe Rao & Xiangxi Wang, 2018. "Structure of the herpes simplex virus type 2 C-capsid with capsid-vertex-specific component," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06078-4
    DOI: 10.1038/s41467-018-06078-4
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