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A plant Bro1 domain protein BRAF regulates multivesicular body biogenesis and membrane protein homeostasis

Author

Listed:
  • Jinbo Shen

    (The Chinese University of Hong Kong
    Zhejiang A&F University)

  • Qiong Zhao

    (The Chinese University of Hong Kong)

  • Xiangfeng Wang

    (The Chinese University of Hong Kong
    China Agricultural University)

  • Caiji Gao

    (The Chinese University of Hong Kong
    South China Normal University (SCNU))

  • Ying Zhu

    (The Chinese University of Hong Kong)

  • Yonglun Zeng

    (The Chinese University of Hong Kong)

  • Liwen Jiang

    (The Chinese University of Hong Kong
    The Chinese University of Hong Kong)

Abstract

Plant development, defense, and many physiological processes rely on the endosomal sorting complex required for transport (ESCRT) machinery to control the homeostasis of membrane proteins by selective vacuolar degradation. Although ESCRT core components are conserved among higher eukaryotes, the regulators that control the function of the ESCRT machinery remain elusive. We recently identified a plant-specific ESCRT component, FREE1, that is essential for multivesicular body/prevacuolar compartment (MVB/PVC) biogenesis and vacuolar sorting of membrane proteins. Here we identify a plant-specific Bro1-domain protein BRAF, which regulates FREE1 recruitment to the MVB/PVC membrane by competitively binding to the ESCRT-I component Vps23. Altogether, we have successfully identified a role for BRAF, whose function as a unique evolutionary ESCRT regulator in orchestrating intraluminal vesicle formation in MVB/PVCs and the sorting of membrane proteins for degradation in plants makes it an important regulatory mechanism underlying the ESCRT machinery in higher eukaryotes.

Suggested Citation

  • Jinbo Shen & Qiong Zhao & Xiangfeng Wang & Caiji Gao & Ying Zhu & Yonglun Zeng & Liwen Jiang, 2018. "A plant Bro1 domain protein BRAF regulates multivesicular body biogenesis and membrane protein homeostasis," Nature Communications, Nature, vol. 9(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05913-y
    DOI: 10.1038/s41467-018-05913-y
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    Cited by:

    1. Yonglun Zeng & Baiying Li & Shuxian Huang & Hongbo Li & Wenhan Cao & Yixuan Chen & Guoyong Liu & Zhenping Li & Chao Yang & Lei Feng & Jiayang Gao & Sze Wan Lo & Jierui Zhao & Jinbo Shen & Yan Guo & Ca, 2023. "The plant unique ESCRT component FREE1 regulates autophagosome closure," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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