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Non-competitive resource exploitation within mosquito shapes within-host malaria infectivity and virulence

Author

Listed:
  • G. Costa

    (Max Planck Institute for Infection Biology (MPIIB))

  • M. Gildenhard

    (Max Planck Institute for Infection Biology (MPIIB))

  • M. Eldering

    (Max Planck Institute for Infection Biology (MPIIB)
    Radboud University Medical Center)

  • R. L. Lindquist

    (German Rheumatism Research Centre (DRFZ))

  • A. E. Hauser

    (German Rheumatism Research Centre (DRFZ)
    Charité-Universitätsmedizin)

  • R. Sauerwein

    (Radboud University Medical Center)

  • C. Goosmann

    (Max Planck Institute for Infection Biology (MPIIB))

  • V. Brinkmann

    (Max Planck Institute for Infection Biology (MPIIB))

  • P. Carrillo-Bustamante

    (Max Planck Institute for Infection Biology (MPIIB))

  • E. A. Levashina

    (Max Planck Institute for Infection Biology (MPIIB))

Abstract

Malaria is a fatal human parasitic disease transmitted by a mosquito vector. Although the evolution of within-host malaria virulence has been the focus of many theoretical and empirical studies, the vector’s contribution to this process is not well understood. Here, we explore how within-vector resource exploitation would impact the evolution of within-host Plasmodium virulence. By combining within-vector dynamics and malaria epidemiology, we develop a mathematical model, which predicts that non-competitive parasitic resource exploitation within-vector restricts within-host parasite virulence. To validate our model, we experimentally manipulate mosquito lipid trafficking and gauge within-vector parasite development and within-host infectivity and virulence. We find that mosquito-derived lipids determine within-host parasite virulence by shaping development (quantity) and metabolic activity (quality) of transmissible sporozoites. Our findings uncover the potential impact of within-vector environment and vector control strategies on the evolution of malaria virulence.

Suggested Citation

  • G. Costa & M. Gildenhard & M. Eldering & R. L. Lindquist & A. E. Hauser & R. Sauerwein & C. Goosmann & V. Brinkmann & P. Carrillo-Bustamante & E. A. Levashina, 2018. "Non-competitive resource exploitation within mosquito shapes within-host malaria infectivity and virulence," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05893-z
    DOI: 10.1038/s41467-018-05893-z
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    Cited by:

    1. Paola Carrillo-Bustamante & Giulia Costa & Lena Lampe & Elena A. Levashina, 2023. "Evolutionary modelling indicates that mosquito metabolism shapes the life-history strategies of Plasmodium parasites," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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