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Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity

Author

Listed:
  • Aida Ferreiro-Iglesias

    (World Health Organization)

  • Corina Lesseur

    (World Health Organization)

  • James McKay

    (World Health Organization)

  • Rayjean J. Hung

    (University of Toronto)

  • Younghun Han

    (Geisel School of Medicine at Dartmouth)

  • Xuchen Zong

    (University of Toronto)

  • David Christiani

    (Massachusetts General Hospital/ Harvard Medical School)

  • Mattias Johansson

    (World Health Organization)

  • Xiangjun Xiao

    (Geisel School of Medicine at Dartmouth)

  • Yafang Li

    (Geisel School of Medicine at Dartmouth)

  • David C. Qian

    (Geisel School of Medicine at Dartmouth)

  • Xuemei Ji

    (Geisel School of Medicine at Dartmouth)

  • Geoffrey Liu

    (University of Toronto)

  • Neil Caporaso

    (National Cancer Institute, National Institutes of Health)

  • Ghislaine Scelo

    (World Health Organization)

  • David Zaridze

    (Russian N.N. Blokhin Cancer Research Centre)

  • Anush Mukeriya

    (Russian N.N. Blokhin Cancer Research Centre)

  • Milica Kontic

    (Clinical Center of Serbia)

  • Simona Ognjanovic

    (International Organization for Cancer Prevention and Research)

  • Jolanta Lissowska

    (Institute of Oncology)

  • Małgorzata Szołkowska

    (National Tuberculosis and Lung Diseases Research Institute)

  • Beata Swiatkowska

    (Nofer Institute of Occupational Medicine)

  • Vladimir Janout

    (University of Olomouc)

  • Ivana Holcatova

    (Charles University)

  • Ciprian Bolca

    (Institute of Pneumology “Marius Nasta”)

  • Milan Savic

    (Department of Thoracic Surgery Clinical Center of Serbia Belgrade)

  • Miodrag Ognjanovic

    (International Organization for Cancer Prevention and Research)

  • Stig Egil Bojesen

    (Herlev and Gentofte Hospital
    Copenhagen University Hospital
    University of Copenhagen)

  • Xifeng Wu

    (The University of Texas MD Anderson Cancer Center)

  • Demetrios Albanes

    (National Cancer Institute, National Institutes of Health)

  • Melinda C. Aldrich

    (Vanderbilt University Medical Center)

  • Adonina Tardon

    (University of Oviedo and CIBERESP, Faculty of Medicine)

  • Ana Fernandez-Somoano

    (University of Oviedo and CIBERESP, Faculty of Medicine)

  • Guillermo Fernandez-Tardon

    (University of Oviedo and CIBERESP, Faculty of Medicine)

  • Loic Marchand

    (Epidemiology Program, University of Hawaii Cancer Center)

  • Gadi Rennert

    (Clalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine)

  • Chu Chen

    (University of Washington School of Public Health and Community Medicine)

  • Jennifer Doherty

    (University of Washington School of Public Health and Community Medicine
    Fred Hutchinson Cancer Research Center)

  • Gary Goodman

    (Swedish Medical Group)

  • Heike Bickeböller

    (University Medical Center, Georg-August-University Göttingen)

  • H-Erich Wichmann

    (Ludwig Maximilians University
    Helmholtz Center Munich, Institute of Epidemiology 2
    Technical University Munich)

  • Angela Risch

    (University of Salzburg and Cancer Cluster Salzburg
    Translational Lung Research Center Heidelberg (TLRC‐H)
    German Center for Lung Research (DZL))

  • Albert Rosenberger

    (University Medical Center, Georg-August-University Göttingen)

  • Hongbing Shen

    (School of Public Health, Nanjing Medical University)

  • Juncheng Dai

    (School of Public Health, Nanjing Medical University)

  • John K. Field

    (University of Liverpool)

  • Michael Davies

    (University of Liverpool)

  • Penella Woll

    (University of Sheffield)

  • M. Dawn Teare

    (University Of Sheffield)

  • Lambertus A. Kiemeney

    (Radboud University Medical Center)

  • Erik H. F. M. Heijden

    (Radboud University Medical Center)

  • Jian-Min Yuan

    (University of Pittsburgh Cancer Institute)

  • Yun-Chul Hong

    (Seoul National University College of Medicine)

  • Aage Haugen

    (National Institute of Occupational Health)

  • Shanbeh Zienolddiny

    (National Institute of Occupational Health)

  • Stephen Lam

    (British Columbia Cancer Agency)

  • Ming-Sound Tsao

    (Princess Margaret Cancer Centre)

  • Mikael Johansson

    (Umeå University)

  • Kjell Grankvist

    (Umeå University)

  • Matthew B. Schabath

    (H. Lee Moffitt Cancer Center and Research Institute)

  • Angeline Andrew

    (Geisel School of Medicine at Dartmouth)

  • Eric Duell

    (Catalan Institute of Oncology (ICO‐IDIBELL))

  • Olle Melander

    (Lund University
    Skåne University Hospital)

  • Hans Brunnström

    (Lund University)

  • Philip Lazarus

    (Washington State University)

  • Susanne Arnold

    (University of Kentucky, Markey Cancer Center)

  • Stacey Slone

    (University of Kentucky, Markey Cancer Center)

  • Jinyoung Byun

    (Geisel School of Medicine at Dartmouth)

  • Ahsan Kamal

    (Geisel School of Medicine at Dartmouth)

  • Dakai Zhu

    (Geisel School of Medicine at Dartmouth)

  • Maria Teresa Landi

    (National Cancer Institute, National Institutes of Health)

  • Christopher I. Amos

    (Geisel School of Medicine at Dartmouth)

  • Paul Brennan

    (World Health Organization)

Abstract

The basis for associations between lung cancer and major histocompatibility complex genes is not completely understood. Here the authors further consider genetic variation within the MHC region in lung cancer patients and identify independent associations within HLA genes that explain MHC lung cancer associations in Europeans and Asian populations.

Suggested Citation

  • Aida Ferreiro-Iglesias & Corina Lesseur & James McKay & Rayjean J. Hung & Younghun Han & Xuchen Zong & David Christiani & Mattias Johansson & Xiangjun Xiao & Yafang Li & David C. Qian & Xuemei Ji & Ge, 2018. "Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05890-2
    DOI: 10.1038/s41467-018-05890-2
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    Cited by:

    1. Erping Long & Jinhu Yin & Ju Hye Shin & Yuyan Li & Bolun Li & Alexander Kane & Harsh Patel & Xinti Sun & Cong Wang & Thong Luong & Jun Xia & Younghun Han & Jinyoung Byun & Tongwu Zhang & Wei Zhao & Ma, 2024. "Context-aware single-cell multiomics approach identifies cell-type-specific lung cancer susceptibility genes," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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