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Overexpressing lncRNA LAIR increases grain yield and regulates neighbouring gene cluster expression in rice

Author

Listed:
  • Ying Wang

    (Fudan University
    Fudan Zhangjiang Institute)

  • Xiaojin Luo

    (Fudan University)

  • Fan Sun

    (Fudan University)

  • Jianhua Hu

    (Fudan Zhangjiang Institute
    Fudan University)

  • Xiaojun Zha

    (Zhejiang Normal University)

  • Wei Su

    (Fudan University
    Fudan University)

  • Jinshui Yang

    (Fudan University)

Abstract

Long noncoding RNAs (lncRNAs) are essential regulators of gene expression in eukaryotes. Despite increasing knowledge on the function of lncRNAs, little is known about their effects on crop yield. Here, we identify a lncRNA transcribed from the antisense strand of neighbouring gene LRK (leucine-rich repeat receptor kinase) cluster named LAIR (LRK Antisense Intergenic RNA). LAIR overexpression increases rice grain yield and upregulates the expression of several LRK genes. Additionally, chromatin immunoprecipitation assay results indicate H3K4me3 and H4K16ac are significantly enriched at the activated LRK1 genomic region. LAIR binds histone modification proteins OsMOF and OsWDR5 in rice cells, which are enriched in LRK1 gene region. Moreover, LAIR is demonstrated to bind 5′ and 3′ untranslated regions of LRK1 gene. Overall, this study reveals the role of lncRNA LAIR in regulating rice grain yield and lncRNAs may be useful targets for crop breeding.

Suggested Citation

  • Ying Wang & Xiaojin Luo & Fan Sun & Jianhua Hu & Xiaojun Zha & Wei Su & Jinshui Yang, 2018. "Overexpressing lncRNA LAIR increases grain yield and regulates neighbouring gene cluster expression in rice," Nature Communications, Nature, vol. 9(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05829-7
    DOI: 10.1038/s41467-018-05829-7
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