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Insights into degradation mechanism of N-end rule substrates by p62/SQSTM1 autophagy adapter

Author

Listed:
  • Do Hoon Kwon

    (Korea University)

  • Ok Hyun Park

    (Korea University
    Korea University)

  • Leehyeon Kim

    (Korea University)

  • Yang Ouk Jung

    (Korea University)

  • Yeonkyoung Park

    (Korea University
    Korea University)

  • Hyeongseop Jeong

    (Korea Basic Science Institute)

  • Jaekyung Hyun

    (Korea Basic Science Institute)

  • Yoon Ki Kim

    (Korea University
    Korea University)

  • Hyun Kyu Song

    (Korea University)

Abstract

p62/SQSTM1 is the key autophagy adapter protein and the hub of multi-cellular signaling. It was recently reported that autophagy and N-end rule pathways are linked via p62. However, the exact recognition mode of degrading substrates and regulation of p62 in the autophagic pathway remain unknown. Here, we present the complex structures between the ZZ-domain of p62 and various type-1 and type-2 N-degrons. The binding mode employed in the interaction of the ZZ-domain with N-degrons differs from that employed by classic N-recognins. It was also determined that oligomerization via the PB1 domain can control functional affinity to the R-BiP substrate. Unexpectedly, we found that self-oligomerization and disassembly of p62 are pH-dependent. These findings broaden our understanding of the functional repertoire of the N-end rule pathway and provide an insight into the regulation of p62 during the autophagic pathway.

Suggested Citation

  • Do Hoon Kwon & Ok Hyun Park & Leehyeon Kim & Yang Ouk Jung & Yeonkyoung Park & Hyeongseop Jeong & Jaekyung Hyun & Yoon Ki Kim & Hyun Kyu Song, 2018. "Insights into degradation mechanism of N-end rule substrates by p62/SQSTM1 autophagy adapter," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05825-x
    DOI: 10.1038/s41467-018-05825-x
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    Cited by:

    1. Jianxiu Zhang & Ying-Ying Wang & Zhao-Qian Pan & Yulu Li & Jianhua Sui & Li-Lin Du & Keqiong Ye, 2022. "Structural mechanism of protein recognition by the FW domain of autophagy receptor Nbr1," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Pureum Jeon & Hyun-Ji Ham & Haneul Choi & Semin Park & Jae-Woo Jang & Sang-Won Park & Dong-Hyung Cho & Hyun-Jeong Lee & Hyun Kyu Song & Masaaki Komatsu & Dohyun Han & Deok-Jin Jang & Jin-A Lee, 2024. "NS1 binding protein regulates stress granule dynamics and clearance by inhibiting p62 ubiquitination," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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