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Resolution of chronic inflammatory disease: universal and tissue-specific concepts

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  • Georg Schett

    (Friedrich-Alexander University Erlangen-Nürnberg and Universitatsklinikum Erlangen)

  • Markus F. Neurath

    (Friedrich-Alexander University Erlangen-Nürnberg and Universitatsklinikum Erlangen)

Abstract

Inflammation and its resolution is under-studied in medicine despite being essential for understanding the development of chronic inflammatory disease. In this review article, we discuss the resolution of inflammation in both a biological and translational context. We introduce the concept of impaired resolution leading to diseases like rheumatoid arthritis, Crohn's disease, and asthma, as well as the cellular and molecular components that contribute to resolution of joint, gut, and lung inflammation, respectively. Finally, we discuss potential intervention strategies for fostering the resolution process, and their implications for the therapy of inflammatory diseases.

Suggested Citation

  • Georg Schett & Markus F. Neurath, 2018. "Resolution of chronic inflammatory disease: universal and tissue-specific concepts," Nature Communications, Nature, vol. 9(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05800-6
    DOI: 10.1038/s41467-018-05800-6
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    Cited by:

    1. Eva Hernandez-Garcia & Evangelia Chrysikou & Anastasia Z. Kalea, 2021. "The Interplay between Housing Environmental Attributes and Design Exposures and Psychoneuroimmunology Profile—An Exploratory Review and Analysis Paper in the Cancer Survivors’ Mental Health Morbidity ," IJERPH, MDPI, vol. 18(20), pages 1-32, October.

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