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Single-particle mass spectrometry with arrays of frequency-addressed nanomechanical resonators

Author

Listed:
  • Eric Sage

    (Univ. Grenoble Alpes, CEA, LETI)

  • Marc Sansa

    (Univ. Grenoble Alpes, CEA, LETI)

  • Shawn Fostner

    (Univ. Grenoble Alpes, CEA, LETI)

  • Martial Defoort

    (Univ. Grenoble Alpes, CEA, LETI)

  • Marc Gély

    (Univ. Grenoble Alpes, CEA, LETI)

  • Akshay K. Naik

    (Indian Institute of Science)

  • Robert Morel

    (Univ. Grenoble Alpes, CEA, CNRS, Grenoble INP, INAC-Spintec)

  • Laurent Duraffourg

    (Univ. Grenoble Alpes, CEA, LETI)

  • Michael L. Roukes

    (California Institute of Technology)

  • Thomas Alava

    (Univ. Grenoble Alpes, CEA, LETI)

  • Guillaume Jourdan

    (Univ. Grenoble Alpes, CEA, LETI)

  • Eric Colinet

    (Univ. Grenoble Alpes, CEA, LETI
    APIX Analytics)

  • Christophe Masselon

    (Université Grenoble-Alpes
    CEA, BIG, Biologie à Grande Echelle
    Inserm, Unité 1038)

  • Ariel Brenac

    (Univ. Grenoble Alpes, CEA, CNRS, Grenoble INP, INAC-Spintec)

  • Sébastien Hentz

    (Univ. Grenoble Alpes, CEA, LETI)

Abstract

One of the main challenges to overcome to perform nanomechanical mass spectrometry analysis in a practical time frame stems from the size mismatch between the analyte beam and the small nanomechanical detector area. We report here the demonstration of mass spectrometry with arrays of 20 multiplexed nanomechanical resonators; each resonator is designed with a distinct resonance frequency which becomes its individual address. Mass spectra of metallic aggregates in the MDa range are acquired with more than one order of magnitude improvement in analysis time compared to individual resonators. A 20 NEMS array is probed in 150 ms with the same mass limit of detection as a single resonator. Spectra acquired with a conventional time-of-flight mass spectrometer in the same system show excellent agreement. We also demonstrate how mass spectrometry imaging at the single-particle level becomes possible by mapping a 4-cm-particle beam in the MDa range and above.

Suggested Citation

  • Eric Sage & Marc Sansa & Shawn Fostner & Martial Defoort & Marc Gély & Akshay K. Naik & Robert Morel & Laurent Duraffourg & Michael L. Roukes & Thomas Alava & Guillaume Jourdan & Eric Colinet & Christ, 2018. "Single-particle mass spectrometry with arrays of frequency-addressed nanomechanical resonators," Nature Communications, Nature, vol. 9(1), pages 1-8, December.
  • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05783-4
    DOI: 10.1038/s41467-018-05783-4
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    Cited by:

    1. John E. Sader & Alfredo Gomez & Adam P. Neumann & Alex Nunn & Michael L. Roukes, 2024. "Data-driven fingerprint nanoelectromechanical mass spectrometry," Nature Communications, Nature, vol. 15(1), pages 1-9, December.

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