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Intracellular interleukin-32γ mediates antiviral activity of cytokines against hepatitis B virus

Author

Listed:
  • Doo Hyun Kim

    (Konkuk University)

  • Eun-Sook Park

    (Konkuk University)

  • Ah Ram Lee

    (Konkuk University)

  • Soree Park

    (Konkuk University)

  • Yong Kwang Park

    (Konkuk University)

  • Sung Hyun Ahn

    (Konkuk University)

  • Hong Seok Kang

    (Konkuk University)

  • Ju Hee Won

    (Konkuk University)

  • Yea Na Ha

    (Konkuk University)

  • ByeongJune Jae

    (Konkuk University)

  • Dong-Sik Kim

    (Korea University College of Medicine)

  • Woo-Chang Chung

    (Korea University)

  • Moon Jung Song

    (Korea University)

  • Kee-Hwan Kim

    (The Catholic University of Korea)

  • Seung Hwa Park

    (Konkuk University)

  • Soo-Hyun Kim

    (Konkuk University)

  • Kyun-Hwan Kim

    (Konkuk University
    Konkuk University)

Abstract

Cytokines are involved in early host defense against pathogen infections. In particular, tumor necrosis factor (TNF) and interferon-gamma (IFN-γ) have critical functions in non-cytopathic elimination of hepatitis B virus (HBV) in hepatocytes. However, the molecular mechanisms and mediator molecules are largely unknown. Here we show that interleukin-32 (IL-32) is induced by TNF and IFN-γ in hepatocytes, and inhibits the replication of HBV by acting intracellularly to suppress HBV transcription and replication. The gamma isoform of IL-32 (IL-32γ) inhibits viral enhancer activities by downregulating liver-enriched transcription factors. Our data are validated in both an in vivo HBV mouse model and primary human hepatocytes. This study thus suggests that IL-32γ functions as intracellular effector in hepatocytes for suppressing HBV replication to implicate a possible mechanism of non-cytopathic viral clearance.

Suggested Citation

  • Doo Hyun Kim & Eun-Sook Park & Ah Ram Lee & Soree Park & Yong Kwang Park & Sung Hyun Ahn & Hong Seok Kang & Ju Hee Won & Yea Na Ha & ByeongJune Jae & Dong-Sik Kim & Woo-Chang Chung & Moon Jung Song & , 2018. "Intracellular interleukin-32γ mediates antiviral activity of cytokines against hepatitis B virus," Nature Communications, Nature, vol. 9(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05782-5
    DOI: 10.1038/s41467-018-05782-5
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