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Nuclear-resident RIG-I senses viral replication inducing antiviral immunity

Author

Listed:
  • GuanQun Liu

    (University of Saskatchewan
    University of Saskatchewan)

  • Yao Lu

    (University of Saskatchewan
    University of Saskatchewan)

  • Sathya N. Thulasi Raman

    (University of Saskatchewan)

  • Fang Xu

    (University of Saskatchewan)

  • Qi Wu

    (University of Saskatchewan
    University of Saskatchewan)

  • Zhubing Li

    (University of Saskatchewan
    University of Saskatchewan)

  • Robert Brownlie

    (University of Saskatchewan)

  • Qiang Liu

    (University of Saskatchewan
    University of Saskatchewan
    University of Saskatchewan)

  • Yan Zhou

    (University of Saskatchewan
    University of Saskatchewan
    University of Saskatchewan)

Abstract

The nucleus represents a cellular compartment where the discrimination of self from non-self nucleic acids is vital. While emerging evidence establishes a nuclear non-self DNA sensing paradigm, the nuclear sensing of non-self RNA, such as that from nuclear-replicating RNA viruses, remains unexplored. Here, we report the identification of nuclear-resident RIG-I actively involved in nuclear viral RNA sensing. The nuclear RIG-I, along with its cytoplasmic counterpart, senses influenza A virus (IAV) nuclear replication leading to a cooperative induction of type I interferon response. Its activation signals through the canonical signaling axis and establishes an effective antiviral state restricting IAV replication. The exclusive signaling specificity conferred by nuclear RIG-I is reinforced by its inability to sense cytoplasmic-replicating Sendai virus and appreciable sensing of hepatitis B virus pregenomic RNA in the nucleus. These results refine the RNA sensing paradigm for nuclear-replicating viruses and reveal a previously unrecognized subcellular milieu for RIG-I-like receptor sensing.

Suggested Citation

  • GuanQun Liu & Yao Lu & Sathya N. Thulasi Raman & Fang Xu & Qi Wu & Zhubing Li & Robert Brownlie & Qiang Liu & Yan Zhou, 2018. "Nuclear-resident RIG-I senses viral replication inducing antiviral immunity," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05745-w
    DOI: 10.1038/s41467-018-05745-w
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    Cited by:

    1. Yan Jiang & Siqi Sun & Yuan Quan & Xin Wang & Yuling You & Xiao Zhang & Yue Zhang & Yin Liu & Bingjing Wang & Henan Xu & Xuetao Cao, 2023. "Nuclear RPSA senses viral nucleic acids to promote the innate inflammatory response," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Haibo Zhang & Keke Xue & Wen Li & Xinyi Yang & Yusen Gou & Xiao Su & Feng Qian & Lei Sun, 2024. "Cullin5 drives experimental asthma exacerbations by modulating alveolar macrophage antiviral immunity," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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