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Visual and modular detection of pathogen nucleic acids with enzyme–DNA molecular complexes

Author

Listed:
  • Nicholas R. Y. Ho

    (National University of Singapore
    Technology and Research)

  • Geok Soon Lim

    (National University of Singapore
    Technology and Research)

  • Noah R. Sundah

    (National University of Singapore
    National University of Singapore)

  • Diana Lim

    (National University Hospital)

  • Tze Ping Loh

    (National University of Singapore
    National University Hospital)

  • Huilin Shao

    (National University of Singapore
    Technology and Research
    National University of Singapore
    National University of Singapore)

Abstract

Rapid, visual detection of pathogen nucleic acids has broad applications in infection management. Here we present a modular detection platform, termed enzyme-assisted nanocomplexes for visual identification of nucleic acids (enVision). The system consists of an integrated circuit of enzyme–DNA nanostructures, which function as independent recognition and signaling elements, for direct and versatile detection of pathogen nucleic acids from infected cells. The built-in enzymatic cascades produce a rapid color readout for the naked eye; the assay is thus fast (

Suggested Citation

  • Nicholas R. Y. Ho & Geok Soon Lim & Noah R. Sundah & Diana Lim & Tze Ping Loh & Huilin Shao, 2018. "Visual and modular detection of pathogen nucleic acids with enzyme–DNA molecular complexes," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05733-0
    DOI: 10.1038/s41467-018-05733-0
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