IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-05684-6.html
   My bibliography  Save this article

Structural conservation in a membrane-enveloped filamentous virus infecting a hyperthermophilic acidophile

Author

Listed:
  • Ying Liu

    (Institut Pasteur, Department of Microbiology)

  • Tomasz Osinski

    (University of Virginia)

  • Fengbin Wang

    (University of Virginia)

  • Mart Krupovic

    (Institut Pasteur, Department of Microbiology)

  • Stefan Schouten

    (NIOZ Royal Netherlands Institute for Sea Research
    Utrecht University)

  • Peter Kasson

    (University of Virginia)

  • David Prangishvili

    (Institut Pasteur, Department of Microbiology)

  • Edward H. Egelman

    (University of Virginia)

Abstract

Different forms of viruses that infect archaea inhabiting extreme environments continue to be discovered at a surprising rate, suggesting that the current sampling of these viruses is sparse. We describe here Sulfolobus filamentous virus 1 (SFV1), a membrane-enveloped virus infecting Sulfolobus shibatae. The virus encodes two major coat proteins which display no apparent sequence similarity with each other or with any other proteins in databases. We have used cryo-electron microscopy at 3.7 Å resolution to show that these two proteins form a nearly symmetrical heterodimer, which wraps around A-form DNA, similar to what has been shown for SIRV2 and AFV1, two other archaeal filamentous viruses. The thin (∼ 20 Å) membrane of SFV1 is mainly archaeol, a lipid species that accounts for only 1% of the host lipids. Our results show how relatively conserved structural features can be maintained across evolution by both proteins and lipids that have diverged considerably.

Suggested Citation

  • Ying Liu & Tomasz Osinski & Fengbin Wang & Mart Krupovic & Stefan Schouten & Peter Kasson & David Prangishvili & Edward H. Egelman, 2018. "Structural conservation in a membrane-enveloped filamentous virus infecting a hyperthermophilic acidophile," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05684-6
    DOI: 10.1038/s41467-018-05684-6
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-05684-6
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-018-05684-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05684-6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.