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Dietary stearic acid regulates mitochondria in vivo in humans

Author

Listed:
  • Deniz Senyilmaz-Tiebe

    (German Cancer Research Center (DKFZ)
    Heidelberg University)

  • Daniel H. Pfaff

    (German Cancer Research Center (DKFZ)
    Heidelberg University Hospital)

  • Sam Virtue

    (Wellcome Trust-MRC Institute of Metabolic Science)

  • Kathrin V. Schwarz

    (University Hospital Heidelberg)

  • Thomas Fleming

    (Heidelberg University Hospital
    German Center for Diabetes Research (DZD)
    University Hospital Heidelberg
    IDC Helmholtz Center Munich)

  • Sandro Altamura

    (University of Heidelberg
    Molecular Medicine Partnership Unit)

  • Martina U. Muckenthaler

    (University of Heidelberg
    Molecular Medicine Partnership Unit)

  • Jürgen G. Okun

    (University Hospital Heidelberg)

  • Antonio Vidal-Puig

    (Wellcome Trust-MRC Institute of Metabolic Science
    Wellcome Trust Sanger Institute)

  • Peter Nawroth

    (Heidelberg University Hospital
    German Center for Diabetes Research (DZD)
    University Hospital Heidelberg
    IDC Helmholtz Center Munich)

  • Aurelio A. Teleman

    (German Cancer Research Center (DKFZ)
    Heidelberg University)

Abstract

Since modern foods are unnaturally enriched in single metabolites, it is important to understand which metabolites are sensed by the human body and which are not. We previously showed that the fatty acid stearic acid (C18:0) signals via a dedicated pathway to regulate mitofusin activity and thereby mitochondrial morphology and function in cell culture. Whether this pathway is poised to sense changes in dietary intake of C18:0 in humans is not known. We show here that C18:0 ingestion rapidly and robustly causes mitochondrial fusion in people within 3 h after ingestion. C18:0 intake also causes a drop in circulating long-chain acylcarnitines, suggesting increased fatty acid beta-oxidation in vivo. This work thereby identifies C18:0 as a dietary metabolite that is sensed by our bodies to control our mitochondria. This could explain part of the epidemiological differences between C16:0 and C18:0, whereby C16:0 increases cardiovascular and cancer risk whereas C18:0 decreases both.

Suggested Citation

  • Deniz Senyilmaz-Tiebe & Daniel H. Pfaff & Sam Virtue & Kathrin V. Schwarz & Thomas Fleming & Sandro Altamura & Martina U. Muckenthaler & Jürgen G. Okun & Antonio Vidal-Puig & Peter Nawroth & Aurelio A, 2018. "Dietary stearic acid regulates mitochondria in vivo in humans," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05614-6
    DOI: 10.1038/s41467-018-05614-6
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    Cited by:

    1. Kari L. Harding & Thien Vu & Rebecca Wysocky & Ramon Malheiros & Kenneth E. Anderson & Ondulla T. Toomer, 2021. "The Effects of Feeding a Whole-in-Shell Peanut-Containing Diet on Layer Performance and the Quality and Chemistry of Eggs Produced," Agriculture, MDPI, vol. 11(11), pages 1-14, November.

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