IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-05608-4.html
   My bibliography  Save this article

Epigenetic dysregulation of naive CD4+ T-cell activation genes in childhood food allergy

Author

Listed:
  • David Martino

    (The University of Melbourne
    Telethon Kids Institute)

  • Melanie Neeland

    (The University of Melbourne)

  • Thanh Dang

    (The University of Melbourne)

  • Joanna Cobb

    (The University of Melbourne)

  • Justine Ellis

    (The University of Melbourne)

  • Alice Barnett

    (The University of Melbourne)

  • Mimi Tang

    (The University of Melbourne)

  • Peter Vuillermin

    (The University of Melbourne
    Barwon Health
    Deakin University)

  • Katrina Allen

    (The University of Melbourne)

  • Richard Saffery

    (The University of Melbourne)

Abstract

Food allergy poses a significant clinical and public health burden affecting 2–10% of infants. Using integrated DNA methylation and transcriptomic profiling, we found that polyclonal activation of naive CD4+ T cells through the T cell receptor results in poorer lymphoproliferative responses in children with immunoglobulin E (IgE)-mediated food allergy. Reduced expression of cell cycle-related targets of the E2F and MYC transcription factor networks, and remodeling of DNA methylation at metabolic (RPTOR, PIK3D, MAPK1, FOXO1) and inflammatory genes (IL1R, IL18RAP, CD82) underpins this suboptimal response. Infants who fail to resolve food allergy in later childhood exhibit cumulative increases in epigenetic disruption at T cell activation genes and poorer lymphoproliferative responses compared to children who resolved food allergy. Our data indicate epigenetic dysregulation in the early stages of signal transduction through the T cell receptor complex, and likely reflects pathways modified by gene–environment interactions in food allergy.

Suggested Citation

  • David Martino & Melanie Neeland & Thanh Dang & Joanna Cobb & Justine Ellis & Alice Barnett & Mimi Tang & Peter Vuillermin & Katrina Allen & Richard Saffery, 2018. "Epigenetic dysregulation of naive CD4+ T-cell activation genes in childhood food allergy," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05608-4
    DOI: 10.1038/s41467-018-05608-4
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-05608-4
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-018-05608-4?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05608-4. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.