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A biodegradable hybrid inorganic nanoscaffold for advanced stem cell therapy

Author

Listed:
  • Letao Yang

    (The State University of New Jersey)

  • Sy-Tsong Dean Chueng

    (The State University of New Jersey)

  • Ying Li

    (The State University of New Jersey)

  • Misaal Patel

    (The State University of New Jersey)

  • Christopher Rathnam

    (The State University of New Jersey)

  • Gangotri Dey

    (The State University of New Jersey)

  • Lu Wang

    (The State University of New Jersey)

  • Li Cai

    (The State University of New Jersey)

  • Ki-Bum Lee

    (The State University of New Jersey
    The State University of New Jersey
    Kyung Hee University)

Abstract

Stem cell transplantation, as a promising treatment for central nervous system (CNS) diseases, has been hampered by crucial issues such as a low cell survival rate, incomplete differentiation, and limited neurite outgrowth in vivo. Addressing these hurdles, scientists have designed bioscaffolds that mimic the natural tissue microenvironment to deliver physical and soluble cues. However, several significant obstacles including burst release of drugs, insufficient cellular adhesion support, and slow scaffold degradation rate remain to be overcome before the full potential of bioscaffold–based stem-cell therapies can be realized. To this end, we developed a biodegradable nanoscaffold-based method for enhanced stem cell transplantation, differentiation, and drug delivery. These findings collectively support the therapeutic potential of our biodegradable hybrid inorganic (BHI) nanoscaffolds for advanced stem cell transplantation and neural tissue engineering.

Suggested Citation

  • Letao Yang & Sy-Tsong Dean Chueng & Ying Li & Misaal Patel & Christopher Rathnam & Gangotri Dey & Lu Wang & Li Cai & Ki-Bum Lee, 2018. "A biodegradable hybrid inorganic nanoscaffold for advanced stem cell therapy," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05599-2
    DOI: 10.1038/s41467-018-05599-2
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    Cited by:

    1. Xin Guan & Liping Sun & Yuting Shen & Fengshan Jin & Xiaowan Bo & Chunyan Zhu & Xiaoxia Han & Xiaolong Li & Yu Chen & Huixiong Xu & Wenwen Yue, 2022. "Nanoparticle-enhanced radiotherapy synergizes with PD-L1 blockade to limit post-surgical cancer recurrence and metastasis," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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