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Lysine benzoylation is a histone mark regulated by SIRT2

Author

Listed:
  • He Huang

    (The University of Chicago)

  • Di Zhang

    (The University of Chicago)

  • Yi Wang

    (University of Hong Kong)

  • Mathew Perez-Neut

    (The University of Chicago)

  • Zhen Han

    (University of Georgia)

  • Y. George Zheng

    (University of Georgia)

  • Quan Hao

    (University of Hong Kong)

  • Yingming Zhao

    (The University of Chicago)

Abstract

Metabolic regulation of histone marks is associated with diverse biological processes through dynamically modulating chromatin structure and functions. Here we report the identification and characterization of a histone mark, lysine benzoylation (Kbz). Our study identifies 22 Kbz sites on histones from HepG2 and RAW cells. This type of histone mark can be stimulated by sodium benzoate (SB), an FDA-approved drug and a widely used chemical food preservative, via generation of benzoyl CoA. By ChIP-seq and RNA-seq analysis, we demonstrate that histone Kbz marks are associated with gene expression and have physiological relevance distinct from histone acetylation. In addition, we demonstrate that SIRT2, a NAD+-dependent protein deacetylase, removes histone Kbz both in vitro and in vivo. This study therefore reveals a new type of histone marks with potential physiological relevance and identifies possible non-canonical functions of a widely used chemical food preservative.

Suggested Citation

  • He Huang & Di Zhang & Yi Wang & Mathew Perez-Neut & Zhen Han & Y. George Zheng & Quan Hao & Yingming Zhao, 2018. "Lysine benzoylation is a histone mark regulated by SIRT2," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05567-w
    DOI: 10.1038/s41467-018-05567-w
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    Cited by:

    1. Misuzu Habazaki & Shinsuke Mizumoto & Hidetoshi Kajino & Tomoya Kujirai & Hitoshi Kurumizaka & Shigehiro A. Kawashima & Kenzo Yamatsugu & Motomu Kanai, 2023. "A chemical catalyst enabling histone acylation with endogenous acyl-CoA," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Duo Wang & Fuxiang Yan & Ping Wu & Kexue Ge & Muchun Li & Tingting Li & Ying Gao & Chao Peng & Yong Chen, 2022. "Global profiling of regulatory elements in the histone benzoylation pathway," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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