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Social interactions impact on the dopaminergic system and drive individuality

Author

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  • N. Torquet

    (Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS))

  • F. Marti

    (Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS))

  • C. Campart

    (Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS))

  • S. Tolu

    (Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS))

  • C. Nguyen

    (Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS))

  • V. Oberto

    (Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS))

  • M. Benallaoua

    (Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS))

  • J. Naudé

    (Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS))

  • S. Didienne

    (Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS))

  • N. Debray

    (Biological Adaptation and Ageing - Institut de Biologie Paris Seine (B2A - IBPS)
    Institut de la Longévité)

  • S. Jezequel

    (Institut de la Longévité
    CNRS UMS)

  • L. Gouestre

    (Institut de la Longévité
    CNRS UMS)

  • B. Hannesse

    (Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS))

  • J. Mariani

    (Biological Adaptation and Ageing - Institut de Biologie Paris Seine (B2A - IBPS)
    Institut de la Longévité)

  • A. Mourot

    (Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS))

  • P. Faure

    (Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS))

Abstract

Individuality is a striking feature of animal behavior. Individual animals differ in traits and preferences which shape their interactions and their prospects for survival. However, the mechanisms underlying behavioral individuation are poorly understood and are generally considered to be genetic-based. Here, we devised a large environment, Souris City, in which mice live continuously in large groups. We observed the emergence of individual differences in social behavior, activity levels, and cognitive traits, even though the animals had low genetic diversity (inbred C57BL/6J strain). We further show that the phenotypic divergence in individual behaviors was mirrored by developing differences in midbrain dopamine neuron firing properties. Strikingly, modifying the social environment resulted in a fast re-adaptation of both the animal’s traits and its dopamine firing pattern. Individuality can rapidly change upon social challenges, and does not just depend on the genetic status or the accumulation of small differences throughout development.

Suggested Citation

  • N. Torquet & F. Marti & C. Campart & S. Tolu & C. Nguyen & V. Oberto & M. Benallaoua & J. Naudé & S. Didienne & N. Debray & S. Jezequel & L. Gouestre & B. Hannesse & J. Mariani & A. Mourot & P. Faure, 2018. "Social interactions impact on the dopaminergic system and drive individuality," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05526-5
    DOI: 10.1038/s41467-018-05526-5
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    Cited by:

    1. Carole Morel & Sarah E. Montgomery & Long Li & Romain Durand-de Cuttoli & Emily M. Teichman & Barbara Juarez & Nikos Tzavaras & Stacy M. Ku & Meghan E. Flanigan & Min Cai & Jessica J. Walsh & Scott J., 2022. "Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Malou Dongelmans & Romain Durand-de Cuttoli & Claire Nguyen & Maxime Come & Etienne K. Duranté & Damien Lemoine & Raphaël Brito & Tarek Ahmed Yahia & Sarah Mondoloni & Steve Didienne & Elise Bousseyro, 2021. "Chronic nicotine increases midbrain dopamine neuron activity and biases individual strategies towards reduced exploration in mice," Nature Communications, Nature, vol. 12(1), pages 1-15, December.

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