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A critical view on transgenerational epigenetic inheritance in humans

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  • Bernhard Horsthemke

    (Universitätsklinikum Essen and Universität Duisburg-Essen)

Abstract

Transgenerational epigenetic inheritance refers to the transmission of epigenetic information through the germline. While it has been observed in plants, nematodes and fruit flies, its occurrence in mammals—and humans in particular—is the matter of controversial debate, mostly because the study of transgenerational epigenetic inheritance is confounded by genetic, ecological and cultural inheritance. In this comment, I discuss the phenomenon of transgenerational epigenetic inheritance and the difficulty of providing conclusive proof for it in experimental and observational studies.

Suggested Citation

  • Bernhard Horsthemke, 2018. "A critical view on transgenerational epigenetic inheritance in humans," Nature Communications, Nature, vol. 9(1), pages 1-4, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05445-5
    DOI: 10.1038/s41467-018-05445-5
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    Cited by:

    1. Mathew Pette & Andrew Dimond & António M. Galvão & Steven J. Millership & Wilson To & Chiara Prodani & Gráinne McNamara & Ludovica Bruno & Alessandro Sardini & Zoe Webster & James McGinty & Paul M. W., 2022. "Epigenetic changes induced by in utero dietary challenge result in phenotypic variability in successive generations of mice," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Sarah M. Orton & Kimberly Millis & Peter Choate, 2023. "Epigenetics of Trauma Transmission and Fetal Alcohol Spectrum Disorder: What Does the Evidence Support?," IJERPH, MDPI, vol. 20(17), pages 1-25, September.
    3. Johanna Beil & Juliane Perner & Lena Pfaller & Marie-Apolline Gérard & Alessandro Piaia & Arno Doelemeyer & Adi Wasserkrug Naor & Lori Martin & Aline Piequet & Valérie Dubost & Salah-Dine Chibout & Jo, 2023. "Unaltered hepatic wound healing response in male rats with ancestral liver injury," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    4. Pilar Zamora-León, 2021. "Are the Effects of DES Over? A Tragic Lesson from the Past," IJERPH, MDPI, vol. 18(19), pages 1-14, September.

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