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A user-friendly herbicide derived from photo-responsive supramolecular vesicles

Author

Listed:
  • Cheng Gao

    (University of Macau)

  • Qiaoxian Huang

    (University of Macau)

  • Qingping Lan

    (University of Macau)

  • Yu Feng

    (University of Macau)

  • Fan Tang

    (University of Macau)

  • Maggie P. M. Hoi

    (University of Macau)

  • Jianxiang Zhang

    (Third Military Medical University)

  • Simon M. Y. Lee

    (University of Macau)

  • Ruibing Wang

    (University of Macau)

Abstract

Paraquat, as one of the most widely used herbicides globally, is highly toxic to humans, and chronic exposure and acute ingestion leads to high morbidity and mortality rates. Here, we report user-friendly, photo-responsive paraquat-loaded supramolecular vesicles, prepared via one-pot self-assembly of amphiphilic, ternary host-guest complexes between cucurbit[8]uril, paraquat, and an azobenzene derivative. In this vesicle formulation, paraquat is only released upon UV or sunlight irradiation that converts the azobenzene derivative from its trans- to its cis- form, which in turn dissociates the ternary host-guest complexations and the vesicles. The cytotoxicity evaluation of this vesicle formulation of paraquat on in vitro cell models, in vivo zebrafish models, and mouse models demonstrates an enhanced safety profile. Additionally, the PQ-loaded vesicles’ herbicidal activity against a model of invasive weed is nearly identical to that of free paraquat under natural sunlight. This study provides a safe yet effective herbicide formulation.

Suggested Citation

  • Cheng Gao & Qiaoxian Huang & Qingping Lan & Yu Feng & Fan Tang & Maggie P. M. Hoi & Jianxiang Zhang & Simon M. Y. Lee & Ruibing Wang, 2018. "A user-friendly herbicide derived from photo-responsive supramolecular vesicles," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05437-5
    DOI: 10.1038/s41467-018-05437-5
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