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Block copolymer crystalsomes with an ultrathin shell to extend blood circulation time

Author

Listed:
  • Hao Qi

    (Drexel University)

  • Hao Zhou

    (Drexel University)

  • Qiyun Tang

    (Universität Göttingen)

  • Jee Young Lee

    (University of Delaware)

  • Zhiyuan Fan

    (Drexel University)

  • Seyong Kim

    (Drexel University)

  • Mark C. Staub

    (Drexel University)

  • Tian Zhou

    (Drexel University)

  • Shan Mei

    (Drexel University)

  • Lin Han

    (Drexel University)

  • Darrin J. Pochan

    (University of Delaware)

  • Hao Cheng

    (Drexel University)

  • Wenbing Hu

    (Nanjing University)

  • Christopher Y. Li

    (Drexel University)

Abstract

In water, amphiphilic block copolymers (BCPs) can self-assemble into various micelle structures depicting curved liquid/liquid interface. Crystallization, which is incommensurate with this curved space, often leads to defect accumulation and renders the structures leaky, undermining their potential biomedical applications. Herein we report using an emulsion-solution crystallization method to control the crystallization of an amphiphilic BCP, poly (l-lactide acid)-b-poly (ethylene glycol) (PLLA-b-PEG), at curved liquid/liquid interface. The resultant BCP crystalsomes (BCCs) structurally mimic the classical polymersomes and liposomes yet mechanically are more robust thanks to the single crystal-like crystalline PLLA shell. In blood circulation and biodistribution experiments, fluorophore-loaded BCCs show a 24 h circulation half-life and a 8% particle retention in the blood even at 96 h post injection. We further demonstrate that this good performance can be attributed to controlled polymer crystallization and the unique BCC nanostructure.

Suggested Citation

  • Hao Qi & Hao Zhou & Qiyun Tang & Jee Young Lee & Zhiyuan Fan & Seyong Kim & Mark C. Staub & Tian Zhou & Shan Mei & Lin Han & Darrin J. Pochan & Hao Cheng & Wenbing Hu & Christopher Y. Li, 2018. "Block copolymer crystalsomes with an ultrathin shell to extend blood circulation time," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05396-x
    DOI: 10.1038/s41467-018-05396-x
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    Cited by:

    1. Huanzhi Yang & Yunjun Luo & Bixin Jin & Shumeng Chi & Xiaoyu Li, 2024. "Convoluted micellar morphological transitions driven by tailorable mesogenic ordering effect from discotic mesogen-containing block copolymer," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

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