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Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation

Author

Listed:
  • Fabrizia Bonacina

    (Università Degli Studi di Milano)

  • David Coe

    (Queen Mary University of London)

  • Guosu Wang

    (Queen Mary University of London)

  • Maria P. Longhi

    (Queen Mary University of London)

  • Andrea Baragetti

    (Università Degli Studi di Milano
    Bassini Hospital)

  • Annalisa Moregola

    (Università Degli Studi di Milano)

  • Katia Garlaschelli

    (Bassini Hospital)

  • Patrizia Uboldi

    (Università Degli Studi di Milano)

  • Fabio Pellegatta

    (Bassini Hospital)

  • Liliana Grigore

    (Bassini Hospital)

  • Lorenzo Dalt

    (Università Degli Studi di Milano)

  • Andrea Annoni

    (IRCCS San Raffaele Scientific Institute)

  • Silvia Gregori

    (IRCCS San Raffaele Scientific Institute)

  • Qingzhong Xiao

    (Queen Mary University of London)

  • Donatella Caruso

    (Università Degli Studi di Milano)

  • Nico Mitro

    (Università Degli Studi di Milano)

  • Alberico L. Catapano

    (Università Degli Studi di Milano
    IRCSS Multimedica)

  • Federica M. Marelli-Berg

    (Queen Mary University of London)

  • Giuseppe D. Norata

    (Università Degli Studi di Milano
    Bassini Hospital)

Abstract

Cholesterol homeostasis has a pivotal function in regulating immune cells. Here we show that apolipoprotein E (apoE) deficiency leads to the accumulation of cholesterol in the cell membrane of dendritic cells (DC), resulting in enhanced MHC-II-dependent antigen presentation and CD4+ T-cell activation. Results from WT and apoE KO bone marrow chimera suggest that apoE from cells of hematopoietic origin has immunomodulatory functions, regardless of the onset of hypercholesterolemia. Humans expressing apoE4 isoform (ε4/3–ε4/4) have increased circulating levels of activated T cells compared to those expressing WT apoE3 (ε3/3) or apoE2 isoform (ε2/3–ε2/2). This increase is caused by enhanced antigen-presentation by apoE4-expressing DCs, and is reversed when these DCs are incubated with serum containing WT apoE3. In summary, our study identifies myeloid-produced apoE as a key physiological modulator of DC antigen presentation function, paving the way for further explorations of apoE as a tool to improve the management of immune diseases.

Suggested Citation

  • Fabrizia Bonacina & David Coe & Guosu Wang & Maria P. Longhi & Andrea Baragetti & Annalisa Moregola & Katia Garlaschelli & Patrizia Uboldi & Fabio Pellegatta & Liliana Grigore & Lorenzo Dalt & Andrea , 2018. "Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation," Nature Communications, Nature, vol. 9(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05322-1
    DOI: 10.1038/s41467-018-05322-1
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    Cited by:

    1. S. John Liu & Tim Casey-Clyde & Nam Woo Cho & Jason Swinderman & Melike Pekmezci & Mark C. Dougherty & Kyla Foster & William C. Chen & Javier E. Villanueva-Meyer & Danielle L. Swaney & Harish N. Vasud, 2024. "Epigenetic reprogramming shapes the cellular landscape of schwannoma," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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