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Single-molecule insights into surface-mediated homochirality in hierarchical peptide assembly

Author

Listed:
  • Yumin Chen

    (National Center for Nanoscience and Technology, China
    Chinese Academy of Sciences)

  • Ke Deng

    (National Center for Nanoscience and Technology, China)

  • Shengbin Lei

    (Tianjin University)

  • Rong Yang

    (National Center for Nanoscience and Technology, China)

  • Tong Li

    (Queensland University of Technology)

  • Yuantong Gu

    (Queensland University of Technology)

  • Yanlian Yang

    (National Center for Nanoscience and Technology, China)

  • Xiaohui Qiu

    (National Center for Nanoscience and Technology, China)

  • Chen Wang

    (National Center for Nanoscience and Technology, China)

Abstract

Homochirality is very important in the formation of advanced biological structures, but the origin and evolution mechanisms of homochiral biological structures in complex hierarchical process is not clear at the single-molecule level. Here we demonstrate the single-molecule investigation of biological homochirality in the hierarchical peptide assembly, regarding symmetry break, chirality amplification, and chirality transmission. We find that homochirality can be triggered by the chirality unbalance of two adsorption configuration monomers. Co-assembly between these two adsorption configuration monomers is very critical for the formation of homochiral assemblies. The site-specific recognition is responsible for the subsequent homochirality amplification and transmission in their hierarchical assembly. These single-molecule insights open up inspired thoughts for understanding biological homochirality and have general implications for designing and fabricating artificial biomimetic hierarchical chiral materials.

Suggested Citation

  • Yumin Chen & Ke Deng & Shengbin Lei & Rong Yang & Tong Li & Yuantong Gu & Yanlian Yang & Xiaohui Qiu & Chen Wang, 2018. "Single-molecule insights into surface-mediated homochirality in hierarchical peptide assembly," Nature Communications, Nature, vol. 9(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05218-0
    DOI: 10.1038/s41467-018-05218-0
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