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MAIT cells protect against pulmonary Legionella longbeachae infection

Author

Listed:
  • Huimeng Wang

    (University of Melbourne)

  • Criselle D’Souza

    (University of Melbourne
    University of Melbourne)

  • Xin Yi Lim

    (University of Melbourne)

  • Lyudmila Kostenko

    (University of Melbourne)

  • Troi J. Pediongco

    (University of Melbourne)

  • Sidonia B. G. Eckle

    (University of Melbourne)

  • Bronwyn S. Meehan

    (University of Melbourne)

  • Mai Shi

    (University of Melbourne)

  • Nancy Wang

    (University of Melbourne)

  • Shihan Li

    (University of Melbourne
    University of Melbourne)

  • Ligong Liu

    (The University of Queensland
    The University of Queensland)

  • Jeffrey Y. W. Mak

    (The University of Queensland
    The University of Queensland)

  • David P. Fairlie

    (The University of Queensland
    The University of Queensland)

  • Yoichiro Iwakura

    (Tokyo University of Science)

  • Jennifer M. Gunnersen

    (University of Melbourne)

  • Andrew W. Stent

    (University of Melbourne)

  • Dale I. Godfrey

    (University of Melbourne
    University of Melbourne)

  • Jamie Rossjohn

    (Monash University
    Monash University
    Cardiff University, School of Medicine)

  • Glen P. Westall

    (Alfred Hospital)

  • Lars Kjer-Nielsen

    (University of Melbourne)

  • Richard A. Strugnell

    (University of Melbourne)

  • James McCluskey

    (University of Melbourne)

  • Alexandra J. Corbett

    (University of Melbourne)

  • Timothy S. C. Hinks

    (University of Melbourne
    University of Oxford)

  • Zhenjun Chen

    (University of Melbourne)

Abstract

Mucosal associated invariant T (MAIT) cells recognise conserved microbial metabolites from riboflavin synthesis. Striking evolutionary conservation and pulmonary abundance implicate them in antibacterial host defence, yet their functions in protection against clinically important pathogens are unknown. Here we show that mouse Legionella longbeachae infection induces MR1-dependent MAIT cell activation and rapid pulmonary accumulation of MAIT cells associated with immune protection detectable in immunocompetent host animals. MAIT cell protection is more evident in mice lacking CD4+ cells, and adoptive transfer of MAIT cells rescues immunodeficient Rag2−/−γC−/− mice from lethal Legionella infection. Protection is dependent on MR1, IFN-γ and GM-CSF, but not IL-17A, TNF or perforin, and enhanced protection is detected earlier after infection of mice antigen-primed to boost MAIT cell numbers before infection. Our findings define a function for MAIT cells in protection against a major human pathogen and indicate a potential role for vaccination to enhance MAIT cell immunity.

Suggested Citation

  • Huimeng Wang & Criselle D’Souza & Xin Yi Lim & Lyudmila Kostenko & Troi J. Pediongco & Sidonia B. G. Eckle & Bronwyn S. Meehan & Mai Shi & Nancy Wang & Shihan Li & Ligong Liu & Jeffrey Y. W. Mak & Dav, 2018. "MAIT cells protect against pulmonary Legionella longbeachae infection," Nature Communications, Nature, vol. 9(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05202-8
    DOI: 10.1038/s41467-018-05202-8
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    Cited by:

    1. Ann-Christin Gnirck & Marie-Sophie Philipp & Alex Waterhölter & Malte Wunderlich & Nikhat Shaikh & Virginia Adamiak & Lena Henneken & Tobias Kautz & Tingting Xiong & Daniela Klaus & Pascal Tomczyk & M, 2023. "Mucosal-associated invariant T cells contribute to suppression of inflammatory myeloid cells in immune-mediated kidney disease," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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