IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-05196-3.html
   My bibliography  Save this article

Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b

Author

Listed:
  • Sunglim Cho

    (University of California)

  • Hyang-Mi Lee

    (University of California)

  • I-Shing Yu

    (National Taiwan University)

  • Youn Soo Choi

    (La Jolla Institute for Allergy and Immunology
    Seoul National University)

  • Hsi-Yuan Huang

    (China Medical University Hospital, China Medical University)

  • Somaye Sadat Hashemifar

    (Toyota Technological Institute)

  • Ling-Li Lin

    (University of California)

  • Mei-Chi Chen

    (University of California)

  • Nikita D. Afanasiev

    (University of California)

  • Aly Azeem Khan

    (Toyota Technological Institute)

  • Shu-Wha Lin

    (National Taiwan University
    National Taiwan University Hospital)

  • Alexander Y. Rudensky

    (Memorial Sloan-Kettering Cancer Center)

  • Shane Crotty

    (La Jolla Institute for Allergy and Immunology
    University of California)

  • Li-Fan Lu

    (University of California
    University of California
    University of California)

Abstract

Reciprocal interactions between B and follicular T helper (Tfh) cells orchestrate the germinal center (GC) reaction, a hallmark of humoral immunity. Abnormal GC responses could lead to the production of pathogenic autoantibodies and the development of autoimmunity. Here we show that miR-146a controls GC responses by targeting multiple CD40 signaling pathway components in B cells; by contrast, loss of miR-146a in T cells does not alter humoral responses. However, specific deletion of both miR-146a and its paralog, miR-146b, in T cells increases Tfh cell numbers and enhanced GC reactions. Thus, our data reveal differential cell-intrinsic regulations of GC B and Tfh cells by miR-146a and miR-146b. Together, members of the miR-146 family serve as crucial molecular brakes to coordinately control GC reactions to generate protective humoral responses without eliciting unwanted autoimmunity.

Suggested Citation

  • Sunglim Cho & Hyang-Mi Lee & I-Shing Yu & Youn Soo Choi & Hsi-Yuan Huang & Somaye Sadat Hashemifar & Ling-Li Lin & Mei-Chi Chen & Nikita D. Afanasiev & Aly Azeem Khan & Shu-Wha Lin & Alexander Y. Rude, 2018. "Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05196-3
    DOI: 10.1038/s41467-018-05196-3
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-05196-3
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-018-05196-3?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05196-3. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.