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Controlled gene and drug release from a liposomal delivery platform triggered by X-ray radiation

Author

Listed:
  • Wei Deng

    (Macquarie University
    University of New South Wales, Sydney)

  • Wenjie Chen

    (Macquarie University)

  • Sandhya Clement

    (Macquarie University
    University of New South Wales, Sydney)

  • Anna Guller

    (Macquarie University
    Macquarie University
    Sechenov University
    University of New South Wales, Sydney)

  • Zhenjun Zhao

    (Macquarie University)

  • Alexander Engel

    (University of Sydney
    Royal North Shore Hospital
    Kolling Institute of Medical Research, Northern Sydney Local Health District)

  • Ewa M. Goldys

    (Macquarie University
    University of New South Wales, Sydney)

Abstract

Liposomes have been well established as an effective drug delivery system, due to simplicity of their preparation and unique characteristics. However conventional liposomes are unsuitable for the on-demand content release, which limits their therapeutic utility. Here we report X-ray-triggerable liposomes incorporating gold nanoparticles and photosensitizer verteporfin. The 6 MeV X-ray radiation induces verteporfin to produce singlet oxygen, which destabilises the liposomal membrane and causes the release of cargos from the liposomal cavity. This triggering strategy is demonstrated by the efficiency of gene silencing in vitro and increased effectiveness of chemotherapy in vivo. Our work indicates the feasibility of a combinatorial treatment and possible synergistic effects in the course of standard radiotherapy combined with chemotherapy delivered via X-ray-triggered liposomes. Importantly, our X-ray-mediated liposome release strategy offers prospects for deep tissue photodynamic therapy, by removing its depth limitation.

Suggested Citation

  • Wei Deng & Wenjie Chen & Sandhya Clement & Anna Guller & Zhenjun Zhao & Alexander Engel & Ewa M. Goldys, 2018. "Controlled gene and drug release from a liposomal delivery platform triggered by X-ray radiation," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05118-3
    DOI: 10.1038/s41467-018-05118-3
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    Cited by:

    1. Alban Guesdon-Vennerie & Patrick Couvreur & Fatoumia Ali & Frédéric Pouzoulet & Christophe Roulin & Immaculada Martínez-Rovira & Guillaume Bernadat & François-Xavier Legrand & Claudie Bourgaux & Cyril, 2022. "Breaking photoswitch activation depth limit using ionising radiation stimuli adapted to clinical application," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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