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Glycan recognition in globally dominant human rotaviruses

Author

Listed:
  • Liya Hu

    (Baylor College of Medicine)

  • Banumathi Sankaran

    (Lawrence Berkeley National Laboratory)

  • Daniel R. Laucirica

    (Baylor College of Medicine)

  • Ketki Patil

    (Baylor College of Medicine)

  • Wilhelm Salmen

    (Baylor College of Medicine)

  • Allan Chris M Ferreon

    (Baylor College of Medicine)

  • Phoebe S. Tsoi

    (Baylor College of Medicine)

  • Yi Lasanajak

    (Emory University School of Medicine)

  • David F. Smith

    (Emory University School of Medicine)

  • Sasirekha Ramani

    (Baylor College of Medicine)

  • Robert L. Atmar

    (Baylor College of Medicine
    Baylor College of Medicine)

  • Mary K. Estes

    (Baylor College of Medicine
    Baylor College of Medicine)

  • Josephine C. Ferreon

    (Baylor College of Medicine)

  • B. V. Venkataram Prasad

    (Baylor College of Medicine
    Baylor College of Medicine)

Abstract

Rotaviruses (RVs) cause life-threatening diarrhea in infants and children worldwide. Recent biochemical and epidemiological studies underscore the importance of histo-blood group antigens (HBGA) as both cell attachment and susceptibility factors for the globally dominant P[4], P[6], and P[8] genotypes of human RVs. How these genotypes interact with HBGA is not known. Here, our crystal structures of P[4] and a neonate-specific P[6] VP8*s alone and in complex with H-type I HBGA reveal a unique glycan binding site that is conserved in the globally dominant genotypes and allows for the binding of ABH HBGAs, consistent with their prevalence. Remarkably, the VP8* of P[6] RVs isolated from neonates displays subtle structural changes in this binding site that may restrict its ability to bind branched glycans. This provides a structural basis for the age-restricted tropism of some P[6] RVs as developmentally regulated unbranched glycans are more abundant in the neonatal gut.

Suggested Citation

  • Liya Hu & Banumathi Sankaran & Daniel R. Laucirica & Ketki Patil & Wilhelm Salmen & Allan Chris M Ferreon & Phoebe S. Tsoi & Yi Lasanajak & David F. Smith & Sasirekha Ramani & Robert L. Atmar & Mary K, 2018. "Glycan recognition in globally dominant human rotaviruses," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05098-4
    DOI: 10.1038/s41467-018-05098-4
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