IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-05072-0.html
   My bibliography  Save this article

Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors

Author

Listed:
  • Thomas Duhen

    (AgonOx, Inc.)

  • Rebekka Duhen

    (Earle A. Chiles Research Institute, Providence Cancer Institute)

  • Ryan Montler

    (AgonOx, Inc.)

  • Jake Moses

    (AgonOx, Inc.)

  • Tarsem Moudgil

    (Earle A. Chiles Research Institute, Providence Cancer Institute)

  • Noel F. de Miranda

    (Leiden University Medical Center)

  • Cheri P. Goodall

    (Earle A. Chiles Research Institute, Providence Cancer Institute)

  • Tiffany C. Blair

    (AgonOx, Inc.)

  • Bernard A. Fox

    (Earle A. Chiles Research Institute, Providence Cancer Institute)

  • Jason E. McDermott

    (Pacific Northwest National Laboratory, Computational Biology and Bioinformatics Group, MSIN: J4-33)

  • Shu-Ching Chang

    (Providence Saint Joseph’s Health)

  • Gary Grunkemeier

    (Providence Saint Joseph’s Health)

  • Rom Leidner

    (Earle A. Chiles Research Institute, Providence Cancer Institute)

  • Richard Bryan Bell

    (Earle A. Chiles Research Institute, Providence Cancer Institute)

  • Andrew D. Weinberg

    (AgonOx, Inc.
    Earle A. Chiles Research Institute, Providence Cancer Institute)

Abstract

Identifying tumor antigen-specific T cells from cancer patients has important implications for immunotherapy diagnostics and therapeutics. Here, we show that CD103+CD39+ tumor-infiltrating CD8 T cells (CD8 TIL) are enriched for tumor-reactive cells both in primary and metastatic tumors. This CD8 TIL subset is found across six different malignancies and displays an exhausted tissue-resident memory phenotype. CD103+CD39+ CD8 TILs have a distinct T-cell receptor (TCR) repertoire, with T-cell clones expanded in the tumor but present at low frequencies in the periphery. CD103+CD39+ CD8 TILs also efficiently kill autologous tumor cells in a MHC-class I-dependent manner. Finally, higher frequencies of CD103+CD39+ CD8 TILs in patients with head and neck cancer are associated with better overall survival. Our data thus describe an approach for detecting tumor-reactive CD8 TILs that will help define mechanisms of existing immunotherapy treatments, and may lead to future adoptive T-cell cancer therapies.

Suggested Citation

  • Thomas Duhen & Rebekka Duhen & Ryan Montler & Jake Moses & Tarsem Moudgil & Noel F. de Miranda & Cheri P. Goodall & Tiffany C. Blair & Bernard A. Fox & Jason E. McDermott & Shu-Ching Chang & Gary Grun, 2018. "Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05072-0
    DOI: 10.1038/s41467-018-05072-0
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-05072-0
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-018-05072-0?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Irma Telarovic & Carmen S. M. Yong & Lisa Kurz & Irene Vetrugno & Sabrina Reichl & Alba Sanchez Fernandez & Hung-Wei Cheng & Rona Winkler & Matthias Guckenberger & Anja Kipar & Burkhard Ludewig & Mart, 2024. "Delayed tumor-draining lymph node irradiation preserves the efficacy of combined radiotherapy and immune checkpoint blockade in models of metastatic disease," Nature Communications, Nature, vol. 15(1), pages 1-23, December.
    2. Rui Sun & Chao Lei & Zhishan Xu & Xuemei Gu & Liu Huang & Liang Chen & Yi Tan & Min Peng & Kavitha Yaddanapudi & Leah Siskind & Maiying Kong & Robert Mitchell & Jun Yan & Zhongbin Deng, 2024. "Neutral ceramidase regulates breast cancer progression by metabolic programming of TREM2-associated macrophages," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    3. Nasser K. Altorki & Zachary H. Walsh & Johannes C. Melms & Jeffery L. Port & Benjamin E. Lee & Abu Nasar & Cathy Spinelli & Lindsay Caprio & Meri Rogava & Patricia Ho & Paul J. Christos & Ashish Saxen, 2023. "Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I–III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Jia-Cheng Lu & Lei-Lei Wu & Yi-Ning Sun & Xiao-Yong Huang & Chao Gao & Xiao-Jun Guo & Hai-Ying Zeng & Xu-Dong Qu & Yi Chen & Dong Wu & Yan-Zi Pei & Xian-Long Meng & Yi-Min Zheng & Chen Liang & Peng-Fe, 2024. "Macro CD5L+ deteriorates CD8+T cells exhaustion and impairs combination of Gemcitabine-Oxaliplatin-Lenvatinib-anti-PD1 therapy in intrahepatic cholangiocarcinoma," Nature Communications, Nature, vol. 15(1), pages 1-23, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05072-0. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.