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Peptide density targets and impedes triple negative breast cancer metastasis

Author

Listed:
  • Daxing Liu

    (The City College of New York. New York
    Northeastern University)

  • Peng Guo

    (The City College of New York. New York
    Boston Children’s Hospital
    Harvard Medical School and Boston Children’s Hospital)

  • Craig McCarthy

    (The City College of New York. New York)

  • Biran Wang

    (The City College of New York. New York)

  • Yu Tao

    (The City College of New York. New York)

  • Debra Auguste

    (The City College of New York. New York
    Northeastern University)

Abstract

The C-X-C chemokine receptor type 4 (CXCR4, CD184) pathway is a key regulator of cancer metastasis. Existing therapeutics that block CXCR4 signaling are dependent on single molecule-receptor interactions or silencing CXCR4 expression. CXCR4 localizes in lipid rafts and forms dimers therefore CXCR4 targeting and signaling may depend on ligand density. Herein, we report liposomes presenting a CXCR4 binding peptide (DV1) as a three-dimensional molecular array, ranging from 9k to 74k molecules μm−2, target triple negative breast cancer (TNBC). TNBC cells exhibit a maxima in binding and uptake of DV1-functionalized liposomes (L-DV1) in vitro at a specific density, which yields a significant reduction in cell migration. This density inhibits metastasis from a primary tumor for 27 days, resulting from peptide density dependent gene regulation. We show that complementing cell membrane receptor expression may be a strategy for targeting cells and regulating signaling.

Suggested Citation

  • Daxing Liu & Peng Guo & Craig McCarthy & Biran Wang & Yu Tao & Debra Auguste, 2018. "Peptide density targets and impedes triple negative breast cancer metastasis," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05035-5
    DOI: 10.1038/s41467-018-05035-5
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    Cited by:

    1. Minglu Zhou & Chendong Liu & Bo Li & Junlin Li & Ping Zhang & Yuan Huang & Lian Li, 2024. "Cell surface patching via CXCR4-targeted nanothreads for cancer metastasis inhibition," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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