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Silver-catalyzed remote Csp3-H functionalization of aliphatic alcohols

Author

Listed:
  • Yuchao Zhu

    (Peking University)

  • Kaimeng Huang

    (Peking University)

  • Jun Pan

    (Peking University)

  • Xu Qiu

    (Peking University)

  • Xiao Luo

    (Peking University)

  • Qixue Qin

    (Peking University)

  • Jialiang Wei

    (Peking University)

  • Xiaojin Wen

    (Peking University)

  • Lizhi Zhang

    (Peking University)

  • Ning Jiao

    (Peking University
    Chinese Academy of Sciences)

Abstract

Aliphatic alcohols are common and bulk chemicals in organic synthesis. The site-selective functionalization of non-activated aliphatic alcohols is attractive but challenging. Herein, we report a silver-catalyzed δ-selective Csp3-H bond functionalization of abundant and inexpensive aliphatic alcohols. Valuable oximonitrile substituted alcohols are easily obtained by using well-designed sulphonyl reagents under simple and mild conditions. This protocol realizes the challenging δ-selective C–C bond formation of simple alkanols.

Suggested Citation

  • Yuchao Zhu & Kaimeng Huang & Jun Pan & Xu Qiu & Xiao Luo & Qixue Qin & Jialiang Wei & Xiaojin Wen & Lizhi Zhang & Ning Jiao, 2018. "Silver-catalyzed remote Csp3-H functionalization of aliphatic alcohols," Nature Communications, Nature, vol. 9(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05014-w
    DOI: 10.1038/s41467-018-05014-w
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    Cited by:

    1. Yiman Gao & Jie Liu & Cong Wei & Yan Li & Kui Zhang & Liangliang Song & Lingchao Cai, 2022. "Photoinduced β-fragmentation of aliphatic alcohol derivatives for forging C–C bonds," Nature Communications, Nature, vol. 13(1), pages 1-9, December.

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