IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-04913-2.html
   My bibliography  Save this article

Pulmonary pericytes regulate lung morphogenesis

Author

Listed:
  • Katsuhiro Kato

    (Max Planck Institute for Molecular Biomedicine, and University of Münster, Faculty of Medicine)

  • Rodrigo Diéguez-Hurtado

    (Max Planck Institute for Molecular Biomedicine, and University of Münster, Faculty of Medicine)

  • Do Young Park

    (Institute of Basic Science (IBS)
    Korea Advanced Institute of Science and Technology (KAIST))

  • Seon Pyo Hong

    (Institute of Basic Science (IBS)
    Korea Advanced Institute of Science and Technology (KAIST))

  • Sakiko Kato-Azuma

    (Max Planck Institute for Molecular Biomedicine, and University of Münster, Faculty of Medicine)

  • Susanne Adams

    (Max Planck Institute for Molecular Biomedicine, and University of Münster, Faculty of Medicine)

  • Martin Stehling

    (Max Planck Institute for Molecular Biomedicine)

  • Britta Trappmann

    (Max Planck Institute for Molecular Biomedicine)

  • Jeffrey L. Wrana

    (Mount Sinai Hospital
    University of Toronto)

  • Gou Young Koh

    (Institute of Basic Science (IBS)
    Korea Advanced Institute of Science and Technology (KAIST))

  • Ralf H. Adams

    (Max Planck Institute for Molecular Biomedicine, and University of Münster, Faculty of Medicine)

Abstract

Blood vessels are essential for blood circulation but also control organ growth, homeostasis, and regeneration, which has been attributed to the release of paracrine signals by endothelial cells. Endothelial tubules are associated with specialised mesenchymal cells, termed pericytes, which help to maintain vessel wall integrity. Here we identify pericytes as regulators of epithelial and endothelial morphogenesis in postnatal lung. Mice lacking expression of the Hippo pathway components YAP and TAZ in pericytes show defective alveologenesis. Mutant pericytes are present in normal numbers but display strongly reduced expression of hepatocyte growth factor leading to impaired activation of the c-Met receptor, which is expressed by alveolar epithelial cells. YAP and TAZ are also required for expression of angiopoietin-1 by pulmonary pericytes, which also controls hepatocyte growth factor expression and thereby alveologenesis in an autocrine fashion. These findings establish that pericytes have important, organ-specific signalling properties and coordinate the behavior of epithelial and vascular cells during lung morphogenesis.

Suggested Citation

  • Katsuhiro Kato & Rodrigo Diéguez-Hurtado & Do Young Park & Seon Pyo Hong & Sakiko Kato-Azuma & Susanne Adams & Martin Stehling & Britta Trappmann & Jeffrey L. Wrana & Gou Young Koh & Ralf H. Adams, 2018. "Pulmonary pericytes regulate lung morphogenesis," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04913-2
    DOI: 10.1038/s41467-018-04913-2
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-04913-2
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-018-04913-2?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yuta Ozaki & Koji Ohashi & Naoya Otaka & Hiroshi Kawanishi & Tomonobu Takikawa & Lixin Fang & Kunihiko Takahara & Minako Tatsumi & Sohta Ishihama & Mikito Takefuji & Katsuhiro Kato & Yuuki Shimizu & Y, 2023. "Myonectin protects against skeletal muscle dysfunction in male mice through activation of AMPK/PGC1α pathway," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Haruko Watanabe-Takano & Katsuhiro Kato & Eri Oguri-Nakamura & Tomohiro Ishii & Koji Kobayashi & Takahisa Murata & Koichiro Tsujikawa & Takaki Miyata & Yoshiaki Kubota & Yasuyuki Hanada & Koichi Nishi, 2024. "Endothelial cells regulate alveolar morphogenesis by constructing basement membranes acting as a scaffold for myofibroblasts," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04913-2. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.