IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-04907-0.html
   My bibliography  Save this article

Prognostic significance of frequent CLDN18-ARHGAP26/6 fusion in gastric signet-ring cell cancer

Author

Listed:
  • Yang Shu

    (Sichuan University and Collaborative Innovation Center
    Sichuan University and Collaborative Innovation Center)

  • Weihan Zhang

    (Sichuan University and Collaborative Innovation Center)

  • Qianqian Hou

    (Sichuan University and Collaborative Innovation Center)

  • Linyong Zhao

    (Sichuan University and Collaborative Innovation Center)

  • Shouyue Zhang

    (Sichuan University and Collaborative Innovation Center)

  • Jiankang Zhou

    (Sichuan University and Collaborative Innovation Center)

  • Xiaohai Song

    (Sichuan University and Collaborative Innovation Center)

  • Yan Zhang

    (Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University)

  • Dan Jiang

    (West China Hospital, Sichuan University)

  • Xinzu Chen

    (Sichuan University and Collaborative Innovation Center)

  • Peiqi Wang

    (Sichuan University)

  • Xuyang Xia

    (Sichuan University and Collaborative Innovation Center)

  • Fei Liao

    (Sichuan University and Collaborative Innovation Center)

  • Dandan Yin

    (Sichuan University and Collaborative Innovation Center)

  • Xiaolong Chen

    (Sichuan University and Collaborative Innovation Center)

  • Xueyan Zhou

    (Sichuan University and Collaborative Innovation Center)

  • Duyu Zhang

    (Sichuan University and Collaborative Innovation Center)

  • Senlin Yin

    (Sichuan University and Collaborative Innovation Center)

  • Kun Yang

    (Sichuan University and Collaborative Innovation Center)

  • Jianping Liu

    (West China Hospital, Sichuan University)

  • Leilei Fu

    (Sichuan University and Collaborative Innovation Center)

  • Lan Zhang

    (Sichuan University and Collaborative Innovation Center)

  • Yuelan Wang

    (Sichuan University and Collaborative Innovation Center)

  • Junlong Zhang

    (West China Hospital, Sichuan University)

  • Yunfei An

    (West China Hospital, Sichuan University)

  • Hua Cheng

    (WuxiNextCODE)

  • Bin Zheng

    (WuxiNextCODE)

  • Hongye Sun

    (WuxiNextCODE)

  • Yinglan Zhao

    (Sichuan University and Collaborative Innovation Center)

  • Yongsheng Wang

    (Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University)

  • Dan Xie

    (Sichuan University and Collaborative Innovation Center
    Sichuan University and Collaborative Innovation Center)

  • Liang Ouyang

    (Sichuan University and Collaborative Innovation Center)

  • Ping Wang

    (Albert Einstein College of Medicine)

  • Wei Zhang

    (Hunan Key Laboratory of Pharmacogenetics, Xiangya Hospital, Central South University)

  • Meng Qiu

    (Cancer Center, West China Hospital, Sichuan University)

  • Xianghui Fu

    (Sichuan University and Collaborative Innovation Center)

  • Lunzhi Dai

    (Sichuan University and Collaborative Innovation Center)

  • Gu He

    (Sichuan University and Collaborative Innovation Center)

  • Hanshuo Yang

    (Sichuan University and Collaborative Innovation Center)

  • Wei Cheng

    (Sichuan University and Collaborative Innovation Center)

  • Li Yang

    (Sichuan University and Collaborative Innovation Center)

  • Bo Liu

    (Sichuan University and Collaborative Innovation Center)

  • Weimin Li

    (West China Hospital, Sichuan University)

  • Biao Dong

    (Sichuan University and Collaborative Innovation Center)

  • Zongguang Zhou

    (Sichuan University and Collaborative Innovation Center)

  • Yuquan Wei

    (Sichuan University and Collaborative Innovation Center)

  • Yong Peng

    (Sichuan University and Collaborative Innovation Center)

  • Heng Xu

    (Sichuan University and Collaborative Innovation Center
    Sichuan University and Collaborative Innovation Center
    West China Hospital, Sichuan University)

  • Jiankun Hu

    (Sichuan University and Collaborative Innovation Center)

Abstract

Signet-ring cell carcinoma (SRCC) has specific epidemiology and oncogenesis in gastric cancer, however, with no systematical investigation for prognostic genomic features. Here we report a systematic investigation conducted in 1868 Chinese gastric cancer patients indicating that signet-ring cells content was related to multiple clinical characteristics and treatment outcomes. We thus perform whole-genome sequencing on 32 pairs of SRC samples, and identify frequent CLDN18-ARHGAP26/6 fusion (25%). With 797 additional patients for validation, prevalence of CLDN18-ARHGAP26/6 fusion is noticed to be associated with signet-ring cell content, age at diagnosis, female/male ratio, and TNM stage. Importantly, patients with CLDN18-ARHGAP26/6 fusion have worse survival outcomes, and get no benefit from oxaliplatin/fluoropyrimidines-based chemotherapy, which is consistent with the fact of chemo-drug resistance acquired in CLDN18-ARHGAP26 introduced cell lines. Overall, this study provides insights into the clinical and genomic features of SRCC, and highlights the importance of frequent CLDN18-ARHGAP26/6 fusions in chemotherapy response for SRCC.

Suggested Citation

  • Yang Shu & Weihan Zhang & Qianqian Hou & Linyong Zhao & Shouyue Zhang & Jiankang Zhou & Xiaohai Song & Yan Zhang & Dan Jiang & Xinzu Chen & Peiqi Wang & Xuyang Xia & Fei Liao & Dandan Yin & Xiaolong C, 2018. "Prognostic significance of frequent CLDN18-ARHGAP26/6 fusion in gastric signet-ring cell cancer," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04907-0
    DOI: 10.1038/s41467-018-04907-0
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-04907-0
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-018-04907-0?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Lino Möhrmann & Maximilian Werner & Małgorzata Oleś & Andreas Mock & Sebastian Uhrig & Arne Jahn & Simon Kreutzfeldt & Martina Fröhlich & Barbara Hutter & Nagarajan Paramasivam & Daniela Richter & Kat, 2022. "Comprehensive genomic and epigenomic analysis in cancer of unknown primary guides molecularly-informed therapies despite heterogeneity," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Pengfei Yu & Can Hu & Guangyu Ding & Xiaoliang Shi & Jingli Xu & Yang Cao & Xiangliu Chen & Wei Wu & Qi Xu & Jingquan Fang & Xingmao Huang & Shaohua Yuan & Hui Chen & Zhizheng Wang & Ling Huang & Fei , 2024. "Mutation characteristics and molecular evolution of ovarian metastasis from gastric cancer and potential biomarkers for paclitaxel treatment," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04907-0. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.